Highly accurate positioning is fundamental to the performance of microsurgery. Vitreoretinal microsurgery in particular is among the most demanding of specialties in terms of positioning accuracy, and is likely to become more so due to the increasing interest in retinal microvascular interventions. Of similar importance when dealing with delicate tissues is precise control of applied force. The lack of it leads to complications such as iatrogenic retinal breaks during membrane peeling. The original research period under this R01 grant was devoted to the basic development of a fully handheld micromanipulator that performs active tremor compensation by sensing its own movement and deflecting its tool tip to counteract the tremor. A full working prototype has been built and tested, and the tremor compensation has been demonstrated;the ground has now been laid for the realization of the fuller potential of this device for the control of both position and force, which may open the way to numerous significant clinical benefits: reducing complications, improving overall outcomes, and possibly enabling new types of procedures.
This research aims to optimize the parameters of the new tremor compensation filter used within Micron, and validate its improved performance with human users in retinal vein cannulation in vitro in porcine cadaver eyes and in ovo in a chick chorioallantoic membrane (CAM) model, and in cell micromanipulation in the biology laboratory. Improved methods for semi automated micromanipulation with Micron will then be developed and validated with human users in patterned laser photocoagulation in vitro and in chick CAM. Methods for force control of Micron will then be developed and validated with human users in membrane peeling and retinal vessel cannulation tasks in vitro and in chick CAM. The active tremor compensation will be tested primarily in cannulation, the scanning technique in patterned laser photocoagulation, and the force control in membrane peeling and vessel cannulation.

Public Health Relevance

This research aims to develop technology that will improve public health outcomes by enhancing the micromanipulation capabilities of microsurgeons and basic researchers. Vitreoretinal microsurgery is the main surgical focus of the project, but the technologies developed are applicable also to otolaryngology, neurosurgery, and other specialties.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB000526-05
Application #
8213478
Study Section
Bioengineering, Technology and Surgical Sciences Study Section (BTSS)
Program Officer
Krosnick, Steven
Project Start
2011-02-01
Project End
2014-01-31
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
5
Fiscal Year
2012
Total Cost
$338,910
Indirect Cost
$82,639
Name
Carnegie-Mellon University
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
052184116
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Yang, Sungwook; MacLachlan, Robert A; Martel, Joseph N et al. (2016) Comparative Evaluation of Handheld Robot-Aided Intraocular Laser Surgery. IEEE Trans Robot 32:246-251
Channa, Roomasa; Iordachita, Iulian; Handa, James T (2016) Robotic Vitreoretinal Surgery. Retina :
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Yang, Sungwook; Lobes Jr, Louis A; Martel, Joseph N et al. (2015) Handheld-automated microsurgical instrumentation for intraocular laser surgery. Lasers Surg Med 47:658-68
He, Xingchi; van Geirt, Vincent; Gehlbach, Peter et al. (2015) IRIS: Integrated Robotic Intraocular Snake. IEEE Int Conf Robot Autom 2015:1764-1769
Gonenc, Berk; Gehlbach, Peter; Taylor, Russell H et al. (2015) Effects of Micro-Vibratory Modulation during Robot-Assisted Membrane Peeling. Rep U S 2015:3811-3816
Gonenc, Berk; Tran, Nhat; Riviere, Cameron N et al. (2015) Force-Based Puncture Detection and Active Position Holding for Assisted Retinal Vein Cannulation. IEEE SICE RSJ Int Conf Multisens Fusion Integr Intell Syst 2015:322-327
Horise, Yuki; He, Xingchi; Gehlbach, Peter et al. (2015) FBG-based sensorized light pipe for robotic intraocular illumination facilitates bimanual retinal microsurgery. Conf Proc IEEE Eng Med Biol Soc 2015:13-6
Yang, Sungwook; MacLachlan, Robert A; Riviere, Cameron N (2015) Manipulator Design and Operation for a Six-Degree-of-Freedom Handheld Tremor-Canceling Microsurgical Instrument. IEEE ASME Trans Mechatron 20:761-772

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