Changes in metabolic levels observed with proton-magnetic-resonance-spectroscopy ('H-MRS) are frequently used to augment the highly sensitive (but not specific) MRI. At 1.5 Tesla, MRS has so far linked anatomy from MRI with the underlying metabolism in cancer, epilepsy, Alzheimer's disease, multiple sclerosis, HIV infection, stroke and other disorders of the central nervous system (CNS). Therefore, it was anticipated that high-magnetic-field (Bo ) 1.5 T) imagers would provide 'H-MRS a much needed boost in sensitivity. Unfortunately, that has not happened: Translating the most useful 2 and 3 dimensional (3D) 'H-MRS techniques to high-Bos has been stymied by high radio-frequency (BI) power requirements; short TZ reducing the signal-to-noise-ratio (SNR) gain; chemical shift misregistration errors; and scarcity of software to shim, design 3D localization, evaluate and display the large 3D MRS data sets. ? ? The long term goal of this competing continuation is to develop and implement 30 'H-MRS methods to address the above issues and perform better at higher BG. They will be extensions of the hybrid techniques developed in the past two cycles.
Specific Aim 1 will exploit the shorter T2s for: (a) 3D coverage by optimal interleaving of """"""""slabs,"""""""" across the volume-of-interest, each thin enough to excite with the available B1 under strong gradients to minimize the misregistration error; and (b) increase the spatial resolution to ((1 ~m )~voxels, and extend coverage all the way to the skull.
Specific Aim 2 will introduce 3D localization into our non-echo, non-localized, whole head 'H-MRS, to provide a rapid, imager-side, lower-resolution """"""""metabolic localizer."""""""" Specific Aim 3 will utilize the increased sensitivity to produce very high spatial resolution, (0.5 - 0.375 ~m )~ voxels, in restricted regions, e.g., the optic nerve or spinal cord, both of which are currently inaccessible. Finally, Specific Aim 4 will develop novel methods to detect and visualize relationships between different metabolites' spatial distributions to simplify the staggering, often confusing, amount of information generated by 3D 'H MRS. ? ? The health relatedness of this project is its extension of increased spatial resolution, volume covered and shorter acquisition time 3D 'H-MRS methods to high, 23 T, magnetic fields, to support ongoing and future studies of CNS metabolism associated with multifocal and diffuse diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB001015-12
Application #
7110321
Study Section
Special Emphasis Panel (ZRG1-DMG (33))
Program Officer
Mclaughlin, Alan Charles
Project Start
1996-07-22
Project End
2008-07-31
Budget Start
2006-09-01
Budget End
2008-07-31
Support Year
12
Fiscal Year
2006
Total Cost
$774,835
Indirect Cost
Name
New York University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Kirov, Ivan I; Liu, Shu; Tal, Assaf et al. (2017) Proton MR spectroscopy of lesion evolution in multiple sclerosis: Steady-state metabolism and its relationship to conventional imaging. Hum Brain Mapp 38:4047-4063
Davitz, Matthew S; Wu, William E; Soher, Brian J et al. (2017) Quantifying global-brain metabolite level changes with whole-head proton MR spectroscopy at 3T. Magn Reson Imaging 35:15-19
Kirov, Ivan I; Wu, William E; Soher, Brian J et al. (2017) Global brain metabolic quantification with whole-head proton MRS at 3 T. NMR Biomed 30:
Mazgaj, Robert; Tal, Assaf; Goetz, Raymond et al. (2016) Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia. Brain Imaging Behav 10:115-23
Meyer, E J; Kirov, I I; Tal, A et al. (2016) Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T. AJNR Am J Neuroradiol 37:2273-2279
Malaspina, Dolores; Kranz, Thorsten M; Heguy, Adriana et al. (2016) Prefrontal neuronal integrity predicts symptoms and cognition in schizophrenia and is sensitive to genetic heterogeneity. Schizophr Res 172:94-100
Glodzik, Lidia; Sollberger, Marc; Gass, Achim et al. (2015) Global N-acetylaspartate in normal subjects, mild cognitive impairment and Alzheimer's disease patients. J Alzheimers Dis 43:939-47
Grossman, Elan J; Kirov, Ivan I; Gonen, Oded et al. (2015) N-acetyl-aspartate levels correlate with intra-axonal compartment parameters from diffusion MRI. Neuroimage 118:334-43
Chawla, S; Ge, Y; Lu, H et al. (2015) Whole-Brain N-Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge. AJNR Am J Neuroradiol 36:2055-61
Wu, W E; Babb, J S; Tal, A et al. (2015) Early glial activation precedes neurodegeneration in the cerebral cortex after SIV infection: a 3D, multivoxel proton magnetic resonance spectroscopy study. HIV Med 16:381-7

Showing the most recent 10 out of 82 publications