This is a competitive renewal application for a bioengineering research partnership (BRP) on breast CT. Over the past 4.3 years, we have developed two breast CT scanners and were the first group to demonstrate the performance of cone beam breast CT in patients, with 94 patients imaged as of January 2007. We also developed the methodology for accurate dose assessment in the pendant breast CT geometry, and have unambiguously shown that excellent quality breast CT images can be produced at radiation levels equal to two view mammography. Good productivity has been achieved in the aims of the previous funding period, with 12 trainees, 14 peer reviewed papers, 11 other papers, 2 chapters, 15 abstracts and 21 invited presentations. In this proposal, we seek to significantly extend the clinical utility of the basic breast CT platform through further technical development combined with clinical evaluation. A new breast CT scanner will be designed and fabricated, utilizing the basic framework of an existing scanner but incorporating a slip ring, pulsed x-rays, and helical acquisition;the system will allow thick fan beam helical scanning for normal operation and cone beam breast imaging for studies using contrast agent injection. In addition to developing new diagnostic imaging modes including contrast kinetic curve assessment, tomosynthesis, breast PET/CT and magnification-mode breast CT, theoretical and numerical analysis methods such as ideal observer assessment and computer aided diagnosis methods are proposed to better understand the fundamental diagnostic potential of breast tomography. We propose further hardware development on the bCT platform so that it will serve as a multifunctional breast cancer analysis and treatment tool, allowing minimally invasive image guided treatment regimes for breast cancer, including robotically guided breast biopsy, radiofrequency ablation, and x-ray ablation. The research plan describes 16 aims in four phases of development (1) new hardware development, (2) analytical tools for improving interpretation and diagnosis, (3) technology development for image guided assessment and treatment of breast cancer, and (4) clinical trials in breast CT diagnosis and treatment. Two nearly identical breast CT scanners will be fabricated and sited at UC Davis and UC San Diego, and patient accrual at two sites will enable the study of over 800 patients, with many cross comparisons. Non-invasive imaging will proceed in Phase II clinical trials, while the minimally invasive studies will be performed in smaller Phase I trials. At the end of this program of research and discovery, breast CT will likely be shown to be a key clinical tool for the diagnosis and treatment of breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB002138-10
Application #
8269559
Study Section
Special Emphasis Panel (ZRG1-SBIB-U (50))
Program Officer
Lopez, Hector
Project Start
2002-09-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
10
Fiscal Year
2012
Total Cost
$1,023,177
Indirect Cost
$214,896
Name
University of California Davis
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Aminololama-Shakeri, Shadi; Abbey, Craig K; Gazi, Peymon et al. (2016) Differentiation of ductal carcinoma in-situ from benign micro-calcifications by dedicated breast computed tomography. Eur J Radiol 85:297-303
Chaudhari, Abhijit J; Ferrero, Andrea; Godinez, Felipe et al. (2016) High-resolution (18)F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study. Br J Radiol 89:20160138
Gazi, Peymon M; Aminololama-Shakeri, Shadi; Yang, Kai et al. (2016) Temporal subtraction contrast-enhanced dedicated breast CT. Phys Med Biol 61:6322-46
Kompaniez-Dunigan, Elysse; Abbey, Craig K; Boone, John M et al. (2015) Adaptation and visual search in mammographic images. Atten Percept Psychophys 77:1081-7
Hernandez, Andrew M; Seibert, J Anthony; Boone, John M (2015) Breast dose in mammography is about 30% lower when realistic heterogeneous glandular distributions are considered. Med Phys 42:6337-48
Nosratieh, Anita; Hernandez, Andrew; Shen, Sam Z et al. (2015) Mean glandular dose coefficients (D(g)N) for x-ray spectra used in contemporary breast imaging systems. Phys Med Biol 60:7179-90
Gazi, Peymon M; Yang, Kai; Burkett Jr, George W et al. (2015) Evolution of spatial resolution in breast CT at UC Davis. Med Phys 42:1973-81
Chen, L; Boone, J M; Abbey, C K et al. (2015) Simulated lesion, human observer performance comparison between thin-section dedicated breast CT images versus computed thick-section simulated projection images of the breast. Phys Med Biol 60:3347-58
Yang, Kai; Burkett, George; Boone, John M (2014) A breast-specific, negligible-dose scatter correction technique for dedicated cone-beam breast CT: a physics-based approach to improve Hounsfield Unit accuracy. Phys Med Biol 59:6487-505
Santos, Jonathan; Chaudhari, Abhijit J; Joshi, Anand A et al. (2014) Non-rigid registration of serial dedicated breast CT, longitudinal dedicated breast CT and PET/CT images using the diffeomorphic demons method. Phys Med 30:713-7

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