This is a competitive renewal application for a bioengineering research partnership (BRP) on breast CT. Over the past 4.3 years, we have developed two breast CT scanners and were the first group to demonstrate the performance of cone beam breast CT in patients, with 94 patients imaged as of January 2007. We also developed the methodology for accurate dose assessment in the pendant breast CT geometry, and have unambiguously shown that excellent quality breast CT images can be produced at radiation levels equal to two view mammography. Good productivity has been achieved in the aims of the previous funding period, with 12 trainees, 14 peer reviewed papers, 11 other papers, 2 chapters, 15 abstracts and 21 invited presentations. In this proposal, we seek to significantly extend the clinical utility of the basic breast CT platform through further technical development combined with clinical evaluation. A new breast CT scanner will be designed and fabricated, utilizing the basic framework of an existing scanner but incorporating a slip ring, pulsed x-rays, and helical acquisition;the system will allow thick fan beam helical scanning for normal operation and cone beam breast imaging for studies using contrast agent injection. In addition to developing new diagnostic imaging modes including contrast kinetic curve assessment, tomosynthesis, breast PET/CT and magnification-mode breast CT, theoretical and numerical analysis methods such as ideal observer assessment and computer aided diagnosis methods are proposed to better understand the fundamental diagnostic potential of breast tomography. We propose further hardware development on the bCT platform so that it will serve as a multifunctional breast cancer analysis and treatment tool, allowing minimally invasive image guided treatment regimes for breast cancer, including robotically guided breast biopsy, radiofrequency ablation, and x-ray ablation. The research plan describes 16 aims in four phases of development (1) new hardware development, (2) analytical tools for improving interpretation and diagnosis, (3) technology development for image guided assessment and treatment of breast cancer, and (4) clinical trials in breast CT diagnosis and treatment. Two nearly identical breast CT scanners will be fabricated and sited at UC Davis and UC San Diego, and patient accrual at two sites will enable the study of over 800 patients, with many cross comparisons. Non-invasive imaging will proceed in Phase II clinical trials, while the minimally invasive studies will be performed in smaller Phase I trials. At the end of this program of research and discovery, breast CT will likely be shown to be a key clinical tool for the diagnosis and treatment of breast cancer.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-SBIB-U (50))
Program Officer
Lopez, Hector
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Schools of Medicine
United States
Zip Code
Yang, Kai; Burkett, George; Boone, John M (2014) A breast-specific, negligible-dose scatter correction technique for dedicated cone-beam breast CT: a physics-based approach to improve Hounsfield Unit accuracy. Phys Med Biol 59:6487-505
Sidky, Emil Y; Chartrand, Rick; Boone, John M et al. (2014) Constrained TpV Minimization for Enhanced Exploitation of Gradient Sparsity: Application to CT Image Reconstruction. IEEE J Transl Eng Health Med 2:
Santos, Jonathan; Chaudhari, Abhijit J; Joshi, Anand A et al. (2014) Non-rigid registration of serial dedicated breast CT, longitudinal dedicated breast CT and PET/CT images using the diffeomorphic demons method. Phys Med 30:713-7
Schwoebel, P R; Boone, John M; Shao, Joe (2014) Studies of a prototype linear stationary x-ray source for tomosynthesis imaging. Phys Med Biol 59:2393-413
Abbey, Craig K; Gallas, Brandon D; Boone, John M et al. (2014) Comparative statistical properties of expected utility and area under the ROC curve for laboratory studies of observer performance in screening mammography. Acad Radiol 21:481-90
McKenney, Sarah E; Seibert, J Anthony; Burkett, George W et al. (2014) Real-time dosimeter employed to evaluate the half-value layer in CT. Phys Med Biol 59:363-77
Zheng, Lin; Chaudhari, Abhijit J; Badawi, Ramsey D et al. (2014) Using global illumination in volume visualization of rheumatoid arthritis CT data. IEEE Comput Graph Appl 34:16-23
Hernandez, Andrew M; Boone, John M (2014) Tungsten anode spectral model using interpolating cubic splines: unfiltered x-ray spectra from 20 kV to 640 kV. Med Phys 41:042101
Bian, Junguo; Yang, Kai; Boone, John M et al. (2014) Investigation of iterative image reconstruction in low-dose breast CT. Phys Med Biol 59:2659-85
Kuo, Hsien-Chi; Giger, Maryellen L; Reiser, Ingrid et al. (2014) Level set segmentation of breast masses in contrast-enhanced dedicated breast CT and evaluation of stopping criteria. J Digit Imaging 27:237-47

Showing the most recent 10 out of 50 publications