Osteoarthritis (OA) is the leading cause of disability worldwide. The inability of non-invasive techniques to quantify disease progression has limited understanding of the pathogenesis of OA. While numerous magnetic resonance imaging (MRI) methods have been proposed for imaging OA, analysis is often limited to a single tissue or performed using subjective scoring systems. We propose advanced three-dimensional MRI methods as well as advanced analysis tools to quantitatively study the spatial and temporal progression of OA across different tissues in the knee joint. This work will lead to a new understanding of OA pathogenesis by revealing relationships between changes in multiple tissues of the entire joint over time. This project aims to develop 3D imaging tools based on MRI to sensitively track changes of OA in all joint tissues simultaneously.
Our specific aims are to (1 develop a robust ultra-short echo time based quantitative DESS method to obtain high-resolution 3D maps of apparent diffusion coefficient (ADC), T2 and T2* in multiple joint tissues, (2) Improve the signal and resolution of whole-joint sodium MRI at 3T using a novel phased array coil, (3) Develop and validate novel 3D analysis tools that will allow us to quantify changes in knee joint tissues spatially and over time and (4) Validate the ability of our protocol and analysis tools to quantitatively detect changes over time in the knees of subjects with OA of the knee. The innovation of this work lies in the development of novel imaging and analysis techniques that simultaneously offer quantitative measures of tissue integrity in cartilage, meniscus, synovium, and bone marrow. This novel data acquisition will be paired with an innovative three-dimensional analysis approach that will allow quantitative assessment of multiple joint tissues at a single time point and over time. The significance of this work is that e will be able to sensitively and quantitatively track changes of OA over time with accurate registration of multiple joint tissues. This will lead to new insights into OA pathogenesis and progression, as we will be able to relate changes in adjacent joint tissues and across time in subjects with OA.

Public Health Relevance

Osteoarthritis affects more than half of the population during their lives and is the leading cause of disability worldwide. Diagnostic imaging of osteoarthritis s often limited to x-ray, but more sensitive and specific imaging is a critical need for development of disease-modifying treatments. This work aims to develop novel 3D imaging approaches using magnetic resonance imaging (MRI), and couple these with three-dimensional analysis that can be used to quantitatively assess joint health across different tissues in osteoarthritis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB002524-12
Application #
9210622
Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Liu, Guoying
Project Start
2003-09-20
Project End
2019-01-31
Budget Start
2017-02-01
Budget End
2018-01-31
Support Year
12
Fiscal Year
2017
Total Cost
$480,158
Indirect Cost
$158,949
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304
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