In this continuing project, our team aims to develop and deploy novel remote encircling many-element transmitter and detector array structures for high-performance high-field magnetic resonance imaging. Whereas conventional wisdom argues for close-fitting body-contoured coils, the new structures we plan to build will eliminate the many practical and fundamental disadvantages of close-fitting many-element arrays, while preserving all degrees of freedom, and enhancing imaging performance through the inclusion of novel RF field elements of unique benefit at high magnetic field strength. After constructing several prototypes for 3 Tesla and 7 Tesla operation, we will demonstrate potential benefits of this new "contact-free" image acquisition technology, whether alone or in combination with targeted local coils, for visualization of disease processes such as pancreatic cancer and hip osteoarthritis, which have proven to be a challenge for traditional MRI approaches. This continuing work follows the successful first funding period of an R01 project which introduced a wide range of technological and methodological innovations to the field of rapid MRI.

Public Health Relevance

This continuing project explores a new paradigm for magnetic resonance (MR) image acquisition, in which large arrays of remote encircling transmitters and detectors are used in place of traditional body coils or close- fitting coil arrays. The new encircling structures, suitable for incorporation within the covers of an MR scanner, will eliminate many of the practical and fundamental difficulties associated with close-fitting coils, while taking advantage of some of the unique features of high-field MR to improve imaging performance. After constructing several prototypes, we will demonstrate the value of this new contact-free image acquisition technology for visualization of common and high-impact disease processes such as pancreatic cancer and hip osteoarthritis, which have proven to be a challenge for traditional MRI approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
3R01EB002568-09S1
Application #
8676096
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Liu, Guoying
Project Start
2013-08-15
Project End
2015-08-14
Budget Start
2013-08-15
Budget End
2015-08-14
Support Year
9
Fiscal Year
2013
Total Cost
$311,477
Indirect Cost
$127,715
Name
New York University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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Deniz, Cem Murat; Brown, Ryan; Lattanzi, Riccardo et al. (2013) Maximum efficiency radiofrequency shimming: Theory and initial application for hip imaging at 7 tesla. Magn Reson Med 69:1379-88
Fleysher, Lazar; Oesingmann, Niels; Brown, Ryan et al. (2013) Noninvasive quantification of intracellular sodium in human brain using ultrahigh-field MRI. NMR Biomed 26:9-19
Brown, Ryan; Storey, Pippa; Geppert, Christian et al. (2013) Breast MRI at 7 Tesla with a bilateral coil and T1-weighted acquisition with robust fat suppression: image evaluation and comparison with 3 Tesla. Eur Radiol 23:2969-78
Patel, Anand S; Duan, Qi; Robson, Philip M et al. (2012) A simple noniterative principal component technique for rapid noise reduction in parallel MR images. NMR Biomed 25:84-92

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