In this continuing project, our team aims to develop and deploy novel remote encircling many-element transmitter and detector array structures for high-performance high-field magnetic resonance imaging. Whereas conventional wisdom argues for close-fitting body-contoured coils, the new structures we plan to build will eliminate the many practical and fundamental disadvantages of close-fitting many-element arrays, while preserving all degrees of freedom, and enhancing imaging performance through the inclusion of novel RF field elements of unique benefit at high magnetic field strength. After constructing several prototypes for 3 Tesla and 7 Tesla operation, we will demonstrate potential benefits of this new """"""""contact-free"""""""" image acquisition technology, whether alone or in combination with targeted local coils, for visualization of disease processes such as pancreatic cancer and hip osteoarthritis, which have proven to be a challenge for traditional MRI approaches. This continuing work follows the successful first funding period of an R01 project which introduced a wide range of technological and methodological innovations to the field of rapid MRI.

Public Health Relevance

This continuing project explores a new paradigm for magnetic resonance (MR) image acquisition, in which large arrays of remote encircling transmitters and detectors are used in place of traditional body coils or close- fitting coil arrays. The new encircling structures, suitable for incorporation within the covers of an MR scanner, will eliminate many of the practical and fundamental difficulties associated with close-fitting coils, while taking advantage of some of the unique features of high-field MR to improve imaging performance. After constructing several prototypes, we will demonstrate the value of this new contact-free image acquisition technology for visualization of common and high-impact disease processes such as pancreatic cancer and hip osteoarthritis, which have proven to be a challenge for traditional MRI approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB002568-10
Application #
8699768
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Liu, Guoying
Project Start
2003-09-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
10
Fiscal Year
2014
Total Cost
$608,553
Indirect Cost
$248,462
Name
New York University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Chen, Gang; Zhang, Bei; Cloos, Martijn A et al. (2018) A highly decoupled transmit-receive array design with triangular elements at 7T. Magn Reson Med 80:2267-2274
Alon, Leeor; Lattanzi, Riccardo; Lakshmanan, Karthik et al. (2018) Transverse slot antennas for high field MRI. Magn Reson Med 80:1233-1242
Vaidya, Manushka V; Sodickson, Daniel K; Collins, Christopher M et al. (2018) Disentangling the effects of high permittivity materials on signal optimization and sample noise reduction via ideal current patterns. Magn Reson Med :
Vaidya, Manushka V; Lazar, Mariana; Deniz, Cem M et al. (2018) Improved detection of fMRI activation in the cerebellum at 7T with dielectric pads extending the imaging region of a commercial head coil. J Magn Reson Imaging 48:431-440
Vaidya, Manushka V; Deniz, Cem M; Collins, Christopher M et al. (2018) Manipulating transmit and receive sensitivities of radiofrequency surface coils using shielded and unshielded high-permittivity materials. MAGMA 31:355-366
Chen, Gang; Collins, Christopher M; Sodickson, Daniel K et al. (2018) A method to assess the loss of a dipole antenna for ultra-high-field MRI. Magn Reson Med 79:1773-1780
Lattanzi, Riccardo; Wiggins, Graham C; Zhang, Bei et al. (2018) Approaching ultimate intrinsic signal-to-noise ratio with loop and dipole antennas. Magn Reson Med 79:1789-1803
Haemer, Gillian G; Vaidya, Manushka; Collins, Christopher M et al. (2018) Approaching ultimate intrinsic specific absorption rate in radiofrequency shimming using high-permittivity materials at 7 Tesla. Magn Reson Med 80:391-399
Brown, Ryan; Lakshmanan, Karthik; Madelin, Guillaume et al. (2016) A flexible nested sodium and proton coil array with wideband matching for knee cartilage MRI at 3T. Magn Reson Med 76:1325-34
Vaidya, Manushka V; Collins, Christopher M; Sodickson, Daniel K et al. (2016) Dependence of B1+ and B1- Field Patterns of Surface Coils on the Electrical Properties of the Sample and the MR Operating Frequency. Concepts Magn Reson Part B Magn Reson Eng 46:25-40

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