The ultimate goal of the project is to develop a comprehensive computational fluid dynamics (CFD) model for pulmonary air flow that utilizes subject-specific airway geometries, spans spatial scales from the largest bronchial airways to alveolar sac, and employs a Computed Tomography (CT) data-driven, multistage approach to provide accurate predictions of regional ventilation and gas transport through the entire moving airway tree. The approach integrates three-dimensional (3D) and one-dimensional (1D) fluid dynamic models supplemented with dynamic CT data through numerical optimization to achieve realistic multi-scale breathing lung simulations. The model will bring about new understanding of air flow, gas transport, and aerosol particle deposition in the lungs.
The specific aims of the project are: (1) Establish efficient techniques for generating subject-specific computational meshes for CFD analysis; (2) Integrate the custom developed 3D CFD model to the 1D gas transport model by developing an efficient algorithm to facilitate 3D to 1D coupling (large to small airways) or 1D to 3D coupling (bronchioles to alveolar ducts) for multi-scale simulation; (3) Develop and experimentally validate a new predictive model of ventilation distribution by linking 3D CFD models to dynamic imaging of ventilation, via 1D flow models; (4) Make available the coupling algorithms and share the databases with the research and clinical communities. We will use the custom developed segmentation software to extract airway geometries from the CT data sets. The CT-image based geometries will then be supplemented with synthetic geometries using the volume filling technique and Voronoi meshing scheme. The 3D-1D coupled CFD simulations will be performed using the above airway geometries. The coupled CFD solutions will be validated through CT experiments and compared with those of the 1D model. The coupling software and databases will be made available to both research and clinical communities through the medical image file archive system. The applications of the model include, but are not limited to, improving pharmaceutical aerosol drug delivery, predicting subject-specific regional ventilation for diagnosis of patterns related to pathologic changes in airway geometry and parenchyma destruction, and predicting long-term effects of environmental pollutants on lung function where environmental exposure has been shown to alter airway structure in early development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB005823-02
Application #
7116923
Study Section
Special Emphasis Panel (ZEB1-OSR-A (M1))
Program Officer
Peng, Grace
Project Start
2005-09-01
Project End
2008-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
2
Fiscal Year
2006
Total Cost
$294,925
Indirect Cost
Name
University of Iowa
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Jahani, Nariman; Yin, Youbing; Hoffman, Eric A et al. (2014) Assessment of regional non-linear tissue deformation and air volume change of human lungs via image registration. J Biomech 47:1626-33
Kumar, Haribalan; Vasilescu, Dragos M; Yin, Youbing et al. (2013) Multiscale imaging and registration-driven model for pulmonary acinar mechanics in the mouse. J Appl Physiol (1985) 114:971-8
Miyawaki, Shinjiro; Tawhai, Merryn H; Hoffman, Eric A et al. (2012) Effect of carrier gas properties on aerosol distribution in a CT-based human airway numerical model. Ann Biomed Eng 40:1495-507
Kumar, Haribalan; Tawhai, Merryn H; Hoffman, Eric A et al. (2011) Steady streaming: A key mixing mechanism in low-Reynolds-number acinar flows. Phys Fluids (1994) 23:41902
Yin, Youbing; Hoffman, Eric A; Ding, Kai et al. (2011) A cubic B-spline-based hybrid registration of lung CT images for a dynamic airway geometric model with large deformation. Phys Med Biol 56:203-18
Tawhai, Merryn H; Lin, Ching-Long (2011) Airway gas flow. Compr Physiol 1:1135-57
Lambert, Andrew R; O'Shaughnessy, Patrick; Tawhai, Merryn H et al. (2011) Regional deposition of particles in an image-based airway model: large-eddy simulation and left-right lung ventilation asymmetry. Aerosol Sci Technol 45:11-25
Yin, Youbing; Choi, Jiwoong; Hoffman, Eric A et al. (2010) Simulation of pulmonary air flow with a subject-specific boundary condition. J Biomech 43:2159-63
Choi, Jiwoong; Xia, Guohua; Tawhai, Merryn H et al. (2010) Numerical study of high-frequency oscillatory air flow and convective mixing in a CT-based human airway model. Ann Biomed Eng 38:3550-71
Tawhai, Merryn H; Lin, Ching-Long (2010) Image-based modeling of lung structure and function. J Magn Reson Imaging 32:1421-31

Showing the most recent 10 out of 21 publications