In this competing renewal grant application entitled "Human MRI to 9.4T and Beyond", the emphasis is on "Beyond". The current grant now concluding supported the development of whole body imaging at 7T, and human head imaging to 9.4T. While refinements continue, the aims of demonstrating feasibility of human MRI at these highest field strengths were achieved. The development and advancement of parallel transmit, parallel transmitters, multi-channel transmission line arrays and B1 shimming were key technologies and methodologies to make these feats possible. Now, with the development of two new whole body MR systems, one at 10.5T for the University of Minnesota, and the other at 11.7T for CEA Neurospin in Saclay, France, a pair of new highest field MR systems are scheduled for delivery. As was the case with 7T and 9.4T, and for 3T and 4T before, magnet technology has often preceded radiofrequency technology in the evolution of MRI. Field strength has stepped ahead of our ability to use it, again. The purpose of this proposal is therefore to solve this problem for the world's most powerful magnets. Innovative new radiofrequency technology, coils, method and techniques are proposed for achieving the first head and body images from these unprecedented new fields. This effort is aimed at not only developing advanced technology and techniques required to safely harness the world's most powerful whole body MR magnets for science, but will safely achieve the highest field, highest signal, highest speed images yet.

Public Health Relevance

This application seeks renewal of the grant: Human MRI to 9.4T and Beyond. With Human MRI to 9.4T achieved, the effort of this proposal is directed to Beyond. A renewed grant will develop the radiofrequency technology and knowhow required to acquire the first, whole-body images at 10.5T and 11.7T.

National Institute of Health (NIH)
Research Project (R01)
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Biomedical Imaging Technology Study Section (BMIT)
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Liu, Guoying
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Schmitter, Sebastian; DelaBarre, Lance; Wu, Xiaoping et al. (2013) Cardiac imaging at 7 Tesla: Single- and two-spoke radiofrequency pulse design with 16-channel parallel excitation. Magn Reson Med 70:1210-9
Wu, Xiaoping; Schmitter, Sebastian; Auerbach, Edward J et al. (2013) Simultaneous multislice multiband parallel radiofrequency excitation with independent slice-specific transmit B1 homogenization. Magn Reson Med 70:630-8
Metzger, Gregory J; Auerbach, Edward J; Akgun, Can et al. (2013) Dynamically applied B1+ shimming solutions for non-contrast enhanced renal angiography at 7.0 Tesla. Magn Reson Med 69:114-26
Emir, Uzay E; Auerbach, Edward J; Van De Moortele, Pierre-Francois et al. (2012) Regional neurochemical profiles in the human brain measured by ýýH MRS at 7 T using local Býýý shimming. NMR Biomed 25:152-60
Snyder, C J; Delabarre, L; Moeller, S et al. (2012) Comparison between eight- and sixteen-channel TEM transceive arrays for body imaging at 7 T. Magn Reson Med 67:954-64
Shrivastava, Devashish; Hanson, Timothy; Kulesa, Jeramy et al. (2011) Radiofrequency heating in porcine models with a "large" 32 cm internal diameter, 7 T (296 MHz) head coil. Magn Reson Med 66:255-63
Deelchand, Dinesh Kumar; Van de Moortele, Pierre-Francois; Adriany, Gregor et al. (2010) In vivo 1H NMR spectroscopy of the human brain at 9.4 T: initial results. J Magn Reson 206:74-80
Wu, Xiaoping; Vaughan, J Thomas; Ugurbil, Kamil et al. (2010) Parallel excitation in the human brain at 9.4 T counteracting k-space errors with RF pulse design. Magn Reson Med 63:524-9
Wu, Xiaoping; Akgun, Can; Vaughan, J Thomas et al. (2010) Adapted RF pulse design for SAR reduction in parallel excitation with experimental verification at 9.4 T. J Magn Reson 205:161-70
Shrivastava, Devashish; Abosch, Aviva; Hanson, Timothy et al. (2010) Effect of the extracranial deep brain stimulation lead on radiofrequency heating at 9.4 Tesla (400.2 MHz). J Magn Reson Imaging 32:600-7

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