High frequency and high sensitivity ultrasound imaging at the frequency range of 30-100MHz is capable of resolving structures almost down to the cellular level. Developing such an imaging modality for clinical use could have a tremendous impact on the diagnostic and therapeutic procedures in many different clinical areas. The cardio-vascular clinician will be able to visualize in great detail the arterial walls of the coronary arteries and the heart interior structure. The diagnostics of cancer using biopsy will be revolutionized as in-situ microscopy could replace the traditional procedure. Imaging guided therapy could be developed since the diagnosed pathology can be localized at a great precision. The technology can enable high resolution intravascular ultrasound (IVUS) imaging and early cancer detection. In this R01 program, we propose to develop novel optical techniques for high-frequency and high-sensitivity ultrasound detection and broadband ultrasound generation. The proposed work is built upon our initial results obtained through a previous exploratory R21 program and some very recent experimental work related to certain proposal aims. To develop this novel imaging technology many technical and scientific problems must be addressed. It is the aim of the work proposed here to investigate the following tasks in detail with an emphasis on the understanding of underlying physical principles and explore a number of candidate device structures to lay down a solid foundation for the future implementation of integrated transducer arrays for intravascular and intra-catheter applications.
The specific aims are: 1. Develop high-frequency and high-sensitivity ultrasound receivers by using microring resonators with very high quality factor resonances, characterize their sensitivity and dynamic range. 2. Develop high-resolution ultrasound receivers using compact microring and microdisk resonator platforms 3. Design integrated optics elements acting as ultrasound generators using photoelastic methods. The LSPR effect of metallic nanoparticles will be exploited [and embedded in polymer waveguide] for efficient conversion of laser power to broadband acoustic signal. 4. Integrate a prototype imaging device. The prototype will consist of at least 8 microring elements forming the receiver array and one or distributed photoacoustic transmitters. Such an imaging device will be tested for potential catheter-based application as a "smart needle" for high resolution imaging of kidney and diagnosing renal diseases. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB007619-01A1
Application #
7388470
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Lopez, Hector
Project Start
2007-09-01
Project End
2011-05-31
Budget Start
2007-09-01
Budget End
2008-05-31
Support Year
1
Fiscal Year
2007
Total Cost
$327,284
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Govindan, Vishnupriya; Ashkenazi, Shai (2012) Bragg waveguide ultrasound detectors. IEEE Trans Ultrason Ferroelectr Freq Control 59:2304-11
Chen, Sung-Liang; Xie, Zhixing; Carson, Paul L et al. (2011) In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy. Opt Lett 36:4017-9
Xie, Zhixing; Chen, Sung-Liang; Ling, Tao et al. (2011) Pure optical photoacoustic microscopy. Opt Express 19:9027-34
Chen, Sung-Liang; Ling, Tao; Guo, L Jay (2011) Low-noise small-size microring ultrasonic detectors for high-resolution photoacoustic imaging. J Biomed Opt 16:056001
Ling, Tao; Chen, Sung-Liang; Guo, L Jay (2011) Fabrication and characterization of high Q polymer micro-ring resonator and its application as a sensitive ultrasonic detector. Opt Express 19:861-9
Baac, Hyoung Won; Ling, Tao; Ashkenazi, Shai et al. (2010) Photo-acoustic concave transmitter for generating high frequency focused ultrasound. Proc SPIE Int Soc Opt Eng 7564:75642M
Won Baac, Hyoung; Ok, Jong G; Park, Hui Joon et al. (2010) Carbon nanotube composite optoacoustic transmitters for strong and high frequency ultrasound generation. Appl Phys Lett 97:234104
Chen, Sung-Liang; Ling, Tao; Huang, Sheng-Wen et al. (2010) Photoacoustic correlation spectroscopy and its application to low-speed flow measurement. Opt Lett 35:1200-2
Baac, Hyoung Won; Ling, Tao; Guo, L Jay (2010) Design and characterization of acoustic 4f imaging system by using an optical microring ultrasound detector. Proc SPIE Int Soc Opt Eng 7564:75642N
Chen, Sung-Liang; Ling, Tao; Huang, Sheng-Wen et al. (2010) Photoacoustic correlation technique for low-speed flow measurement. Proc SPIE Int Soc Opt Eng 7564:75642I

Showing the most recent 10 out of 14 publications