Widespread use of magnetic resonance spectroscopic imaging techniques is hindered by several challenges, including low signal-to-noise ratio (SNR), inhomogeneity of the main field and RF excitation field, cumbersome constraints on imaging time and volumetric coverage, and limited ability to detect and separate signals from coupled or overlapping spectral components. We address these limitations by developing spectroscopic acquisition and processing methods for i) high field strength (3T and 7T), providing higher SNR, increased chemical shift dispersion and simplified coupling patterns;ii) spiral readout gradients that address the spatial encoding limitations in MRSI by offering two orders of magnitude of encoding acceleration;iii) parallel RF transmission to mitigate the severe non-uniformity of RF excitation at high field;and iv) receive coil arrays to improve SNR and enable parallel encoding. Several attractive spectroscopic imaging applications provide a strong motivation for this work, including volumetric, high spatial resolution spectroscopic imaging, greatly reduced scan times for improved patient tolerance, and the incorporation of multidimensional methods to detect subtly different chemical shift species.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB007942-03
Application #
7797676
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Liu, Guoying
Project Start
2008-04-01
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
3
Fiscal Year
2010
Total Cost
$338,914
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Mahmood, Zohaib; McDaniel, Patrick; Guérin, Bastien et al. (2016) General design approach and practical realization of decoupling matrices for parallel transmission coils. Magn Reson Med 76:329-39
Eryaman, Yigitcan; Guerin, Bastien; Akgun, Can et al. (2015) Parallel transmit pulse design for patients with deep brain stimulation implants. Magn Reson Med 73:1896-903
Guérin, Bastien; Gebhardt, Matthias; Serano, Peter et al. (2015) Comparison of simulated parallel transmit body arrays at 3 T using excitation uniformity, global SAR, local SAR, and power efficiency metrics. Magn Reson Med 73:1137-50
Eryaman, Yigitcan; Guerin, Bastien; Keil, Boris et al. (2015) SAR reduction in 7T C-spine imaging using a ""dark modes"" transmit array strategy. Magn Reson Med 73:1533-9
Guérin, Bastien; Gebhardt, Matthias; Cauley, Steven et al. (2014) Local specific absorption rate (SAR), global SAR, transmitter power, and excitation accuracy trade-offs in low flip-angle parallel transmit pulse design. Magn Reson Med 71:1446-57
Fan, Audrey P; Bilgic, Berkin; Gagnon, Louis et al. (2014) Quantitative oxygenation venography from MRI phase. Magn Reson Med 72:149-59
Bilgic, Berkin; Chatnuntawech, Itthi; Fan, Audrey P et al. (2014) Fast image reconstruction with L2-regularization. J Magn Reson Imaging 40:181-91
Bilgic, Berkin; Chatnuntawech, Itthi; Setsompop, Kawin et al. (2013) Fast dictionary-based reconstruction for diffusion spectrum imaging. IEEE Trans Med Imaging 32:2022-33
Weller, Daniel S; Polimeni, Jonathan R; Grady, Leo et al. (2013) Sparsity-promoting calibration for GRAPPA accelerated parallel MRI reconstruction. IEEE Trans Med Imaging 32:1325-35
Bilgic, Berkin; Gagoski, Borjan; Kok, Trina et al. (2013) Lipid suppression in CSI with spatial priors and highly undersampled peripheral k-space. Magn Reson Med 69:1501-11

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