This work aims for rapid, robust pediatric body MRI. MRI is an excellent tool for diagnosis and monitoring of pediatric disease, offering superb soft tissue contrast and high anatomic resolution;unlike computed tomography (CT), particularly attractive is the lack of ionizing radiation, given the increased risk of children to radiation-induced cancer. However, the impact of MRI in children is limited by (1) lack of robustness from the technical demands and low signal to noise ratio (SNR) of imaging small moving structures in an often uncooperative patient, (2) long exams that limit access, cause motion artifacts, and often require anesthesia with attendant risk, and (3) research and development mostly focused on adults. Thus, children often lack the benefits of cross-sectional imaging altogether or are exposed to ionizing radiation. Approach: This work will (1) increase SNR by developing high-density 3 Tesla receive coils optimized for children and (2) incorporate new k-space sampling strategies, advanced motion correction techniques, and novel non-linear parallel imaging reconstruction methods to reduce image reconstruction failure and motion artifacts, thereby increasing robustness. These two developments will enable a third development, (3) compressed sensing, which enables a further increase in imaging speed by exploiting image sparsity to undersample data without causing image artifacts. The three approaches will synergize for dramatic speed, resolution, and anatomic coverage improvements. Experiments will assess (1) SNR gains of a dedicated pediatric coil, (2) image quality of standard acceleration methods versus parallel imaging enhanced with incoherent sampling, pseudorandom ordering, motion- correction, and nonlinear reconstruction, (3) diagnostic equivalence between parallel imaging alone and further accelerated imaging from combined parallel imaging and compressed sensing, and (4) the ability of these methods to reduce anesthesia for pediatric MRI. Significance: This work will lead to fast, robust, broadly-applicable pediatric body MRI protocols with less anesthesia, making MRI safer, cheaper, and more available to children, transforming it into a workhorse modality and decreasing CT radiation burden. The techniques will demand less MRI operator skill, facilitating wide application in the community setting. Finally, faster imaging and motion compensation will permit new MRI applications, for both pediatric and adult disease.

Public Health Relevance

Pediatric body MRI poses unique challenges of imaging small moving anatomic structures without patient cooperation, resulting in a need for anesthesia, long exam times, and lack of robustness. We will exploit synergies of high field strength, high density receive coils, new motion correction strategies, and novel imaging acceleration methods to dramatically improve image quality and speed. This work will ultimately enable more body MRI exams to be performed robustly without sedation or anesthesia, thus increasing MRI safety and availability and decreasing the dose of ionizing radiation from CT to a particularly vulnerable population.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Research Project (R01)
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Biomedical Imaging Technology Study Section (BMIT)
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Liu, Guoying
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Stanford University
Schools of Medicine
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Zhang, Tao; Grafendorfer, Thomas; Cheng, Joseph Y et al. (2016) A semiflexible 64-channel receive-only phased array for pediatric body MRI at 3T. Magn Reson Med 76:1015-21
Yoruk, Umit; Saranathan, Manojkumar; Loening, Andreas M et al. (2016) High temporal resolution dynamic MRI and arterial input function for assessment of GFR in pediatric subjects. Magn Reson Med 75:1301-11
Zhang, Tao; Chen, Yuxin; Bao, Shanshan et al. (2016) Resolving phase ambiguity in dual-echo dixon imaging using a projected power method. Magn Reson Med :
Levine, Evan; Daniel, Bruce; Vasanawala, Shreyas et al. (2016) 3D Cartesian MRI with compressed sensing and variable view sharing using complementary poisson-disc sampling. Magn Reson Med :
Cheng, Joseph Y; Hanneman, Kate; Zhang, Tao et al. (2016) Comprehensive motion-compensated highly accelerated 4D flow MRI with ferumoxytol enhancement for pediatric congenital heart disease. J Magn Reson Imaging 43:1355-68
Lai, Lillian M; Cheng, Joseph Y; Alley, Marcus T et al. (2016) Feasibility of ferumoxytol-enhanced neonatal and young infant cardiac MRI without general anesthesia. J Magn Reson Imaging :
Hanneman, Kate; Kino, Aya; Cheng, Joseph Y et al. (2016) Assessment of the precision and reproducibility of ventricular volume, function, and mass measurements with ferumoxytol-enhanced 4D flow MRI. J Magn Reson Imaging 44:383-92
Uecker, Martin; Lustig, Michael (2016) Estimating absolute-phase maps using ESPIRiT and virtual conjugate coils. Magn Reson Med :
Chen, Feiyu; Zhang, Tao; Cheng, Joseph Y et al. (2016) Autocalibrating motion-corrected wave-encoding for highly accelerated free-breathing abdominal MRI. Magn Reson Med :
Zhang, Tao; Cheng, Joseph Y; Chen, Yuxin et al. (2016) Robust self-navigated body MRI using dense coil arrays. Magn Reson Med 76:197-205

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