We propose to clinically evaluate the ability of a novel intracardiac ARFI ultrasound imaging system combined with an electro-anatomic mapping system to guide radio-frequency ablations procedures for treating atrial fibrillation and atrial flutter. In parallel, and in collaboration with our industrial partner Siemens Ultrasound, we will migrate these technologies to a 3D ultrasonic imaging platform and develop two intracardiac probes optimized for combined 3D B-mode/ARFI imaging. Phantom, animal and, ultimately, human studies are proposed to evaluate the 3D scanner/probes and the related pulse sequences, beam forming methods and signal and image processing methods to be developed. If successful, the proposed methods will provide the electrophysiologist with real-time visualization of cardiac ablation lesions and with the ability guide the creation of these lesions. As such, the proposed studies could markedly reduce treatment times for atrial and ventricular cardiac ablation procedures, prevent complications from over ablation and reduce the rates of repeat procedures.
We propose to move from the laboratory to the clinic the technique we developed in Phase I for image guided ablation therapy. This system can show the physician regions of the heart which have already been treated. Currently physicians have no means to examine these regions. In Phase I we successfully built the system and demonstrated its efficacy. In phase II we plan a series of clinical tests to demonstrate its utility for treating atrial arrhythmias in patients.
|Vejdani-Jahromi, Maryam; Nagle, Mathew; Jiang, Yang et al. (2016) A Comparison of Acoustic Radiation Force-Derived Indices of Cardiac Function in the Langendorff Perfused Rabbit Heart. IEEE Trans Ultrason Ferroelectr Freq Control 63:1288-95|
|Vejdani-Jahromi, Maryam; Freedman, Jenna; Nagle, Matthew et al. (2016) Quantifying Myocardial Contractility Changes Using Ultrasound-Based Shear Wave Elastography. J Am Soc Echocardiogr :|
|Hollender, Peter J; Rosenzweig, Stephen J; Nightingale, Kathryn R et al. (2015) Single- and multiple-track-location shear wave and acoustic radiation force impulse imaging: matched comparison of contrast, contrast-to-noise ratio and resolution. Ultrasound Med Biol 41:1043-57|
|Vejdani-Jahromi, Maryam; Nagle, Matt; Trahey, Gregg E et al. (2015) Ultrasound shear wave elasticity imaging quantifies coronary perfusion pressure effect on cardiac compliance. IEEE Trans Med Imaging 34:465-73|
|Hollender, Peter; Bottenus, Nick; Trahey, Gregg (2015) A multiresolution approach to shear wave image reconstruction. IEEE Trans Ultrason Ferroelectr Freq Control 62:1429-39|
|Eyerly, Stephanie A; Vejdani-Jahromi, Maryam; Dumont, Douglas M et al. (2015) The Evolution of Tissue Stiffness at Radiofrequency Ablation Sites During Lesion Formation and in the Peri-Ablation Period. J Cardiovasc Electrophysiol :|
|Bahnson, Tristram D; Eyerly, Stephanie A; Hollender, Peter J et al. (2014) Feasibility of near real-time lesion assessment during radiofrequency catheter ablation in humans using acoustic radiation force impulse imaging. J Cardiovasc Electrophysiol 25:1275-83|
|Byram, Brett; Kim, Han; Van Assche, Lowie et al. (2014) The feasibility of myocardial infarct visualization using atrial kick induced strain (AKIS) contrast. Ultrasound Med Biol 40:1104-17|
|Vejdani-Jahromi, Maryam; Kiplagat, Annette; Trahey, Gregg E et al. (2014) The effect of acute coronary perfusion change on cardiac function measured by Shear Wave Elasticity Imaging. Conf Proc IEEE Eng Med Biol Soc 2014:5072-5|
|Eyerly, Stephanie A; Bahnson, Tristram D; Koontz, Jason I et al. (2014) Contrast in intracardiac acoustic radiation force impulse images of radiofrequency ablation lesions. Ultrason Imaging 36:133-48|
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