We will develop hardware, software and novel contrast agents for a new angiographic imaging modality called Magnetic Particle Imaging, which is completely different from X-ray, CT and MRI. Currently available angiographic contrast agents (iodine for X-ray and gadolinium for MRI) are dangerous for Chronic Kidney Disease patients. Magnetic Particle Imaging offers excellent image quality and the contrast agents are completely safe for Chronic Kidney Disease patients. This research will remove the final obstacles to a major medical breakthrough for Chronic Kidney Disease patients.

Public Health Relevance

We will develop hardware, software and novel contrast agents for a new angiographic imaging modality called Magnetic Particle Imaging, which is completely different from X-ray, CT and MRI. Currently available angiographic contrast agents (iodine for X-ray and gadolinium for MRI) are dangerous for Chronic Kidney Disease patients;Magnetic Particle Imaging offers excellent image quality and the contrast agents are completely safe for Chronic Kidney Disease patients. This research will remove the final obstacles to a major medical breakthrough for Chronic Kidney Disease patients.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
5R01EB013689-04
Application #
8665423
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Liu, Christina
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Biomedical Engineering
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Dhavalikar, R; Hensley, D; Maldonado-Camargo, L et al. (2016) Finite magnetic relaxation in x-space magnetic particle imaging: Comparison of measurements and ferrohydrodynamic models. J Phys D Appl Phys 49:
Tay, Zhi Wei; Goodwill, Patrick W; Hensley, Daniel W et al. (2016) A High-Throughput, Arbitrary-Waveform, MPI Spectrometer and Relaxometer for Comprehensive Magnetic Particle Optimization and Characterization. Sci Rep 6:34180
Bao, Yuping; Wen, Tianlong; Samia, Anna Cristina S et al. (2016) Magnetic Nanoparticles: Material Engineering and Emerging Applications in Lithography and Biomedicine. J Mater Sci 51:513-553
Croft, Laura R; Goodwill, Patrick W; Konkle, Justin J et al. (2016) Low drive field amplitude for improved image resolution in magnetic particle imaging. Med Phys 43:424
Zheng, Bo; von See, Marc P; Yu, Elaine et al. (2016) Quantitative Magnetic Particle Imaging Monitors the Transplantation, Biodistribution, and Clearance of Stem Cells In Vivo. Theranostics 6:291-301
Tomitaka, Asahi; Ferguson, Richard Matthew; Khandhar, Amit P et al. (2015) Variation of Magnetic Particle Imaging Tracer Performance With Amplitude and Frequency of the Applied Magnetic Field. IEEE Trans Magn 51:
Hufschmid, Ryan; Arami, Hamed; Ferguson, R Matthew et al. (2015) Synthesis of phase-pure and monodisperse iron oxide nanoparticles by thermal decomposition. Nanoscale 7:11142-54
Konkle, Justin J; Goodwill, Patrick W; Hensley, Daniel W et al. (2015) A Convex Formulation for Magnetic Particle Imaging X-Space Reconstruction. PLoS One 10:e0140137
Arami, Hamed; Khandhar, Amit; Liggitt, Denny et al. (2015) In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles. Chem Soc Rev 44:8576-607
Zheng, Bo; Vazin, Tandis; Goodwill, Patrick W et al. (2015) Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast. Sci Rep 5:14055

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