The MIDAS (Metabolic Imaging Data Analysis System) software package provides comprehensive and unique functionality for processing, display, and analysis of MR Spectroscopic imaging (MRSI) data, and includes close integration with information available from structural and other parametric MRI modalities. This system supports a volumetric echo- planar spectroscopic imaging (EPSI) acquisition that provides high-resolution images of a wide extent of the brain, including cortical surface regions, which has been implemented on MR instruments from three major manufacturers. The EPSI and MIDAS software have been distributed to multiple sites worldwide. Under four specific aims this project will maintain and develop new functionality for these packages.
Aim 1 will add new spectroscopy and image processing functions, which will include capabilities for volumetric mapping of brain temperature, metabolite T2, and parametric changes between studies.
Aim 2 will improve performance, software organization, and maintainability by refactoring historically diverse pieces of code under a common programming environment.
Aim 3 will support the EPSI acquisition through future system upgrades and add new capabilities to the data acquisition methods.
Aim 4 will continue development of user documentation, educational materials, and the project web site, and make available data acquired under previous projects. Through these aims this project will provide continued support and development for a highly innovative suite of functions that facilitate clinical and basic biomedical imaging research studies using MRI and MRSI.

Public Health Relevance

This project will further develop, maintain, and make available to other investigators novel data acquisition and processing software packages that provide volumetric non-invasive mapping of tissue metabolites using magnetic resonance spectroscopy. The developed methods have widespread applications for clinical diagnostic purposes and biomedical studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB016064-01A1
Application #
8573455
Study Section
Biodata Management and Analysis Study Section (BDMA)
Program Officer
Pai, Vinay Manjunath
Project Start
2013-09-20
Project End
2017-08-31
Budget Start
2013-09-20
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$250,001
Indirect Cost
$85,991
Name
University of Miami School of Medicine
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Sabati, Mohammad; Sheriff, Sulaiman; Gu, Meng et al. (2015) Multivendor implementation and comparison of volumetric whole-brain echo-planar MR spectroscopic imaging. Magn Reson Med 74:1209-20