Many biochemically interesting molecules, including the inhibitory and excitatory neurotransmitters GABA and aspartate, the redox compounds glutathione and ascorbate, and the neuromodulator N- acetylaspartylglutamate can be measured in the human brain non-invasively using edited 1H magnetic resonance spectroscopy (MRS). Until very recently, edited MRS has been applied as a single-metbaolite single-voxel method ? i.e. requiring a 10-minute acquisition to measure GABA, and additional experiments to measure other metabolites. This has substantially limited the breadth of application of edited MRS in clinical studies, and particularly studies of, for example, interactions between different systems. The overall goal of this grant is the development of a universal acquisition and processing pipeline for measuring levels of all these editable metabolites in the human brain from a single experiment. We will develop a single sequence, implemented on all three major vendor platforms, for multiplexed editing 3T, the Gannet Toolkit for quantitative data analysis, and demonstrate the cross-platform equivalence of the new measurement. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.

Public Health Relevance

Edited magnetic resonance spectroscopy measures the concentration of a single naturally occurring chemical within the body using an MRI scanner. This project will develop new experimental and data processing tools to allow edited measurements of many brain chemicals at the same time, increasing the efficiency of data acquisition while maintaining the separation of editing.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
2R01EB016089-05
Application #
9523091
Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Liu, Guoying
Project Start
2013-08-01
Project End
2022-04-30
Budget Start
2018-08-01
Budget End
2019-04-30
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Neurology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Kurcyus, Katarzyna; Annac, Efsun; Hanning, Nina M et al. (2018) Opposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing. J Neurosci 38:9967-9976
Oeltzschner, Georg; Chan, Kimberly L; Saleh, Muhammad G et al. (2018) Hadamard editing of glutathione and macromolecule-suppressed GABA. NMR Biomed 31:
Gong, Tao; Xiang, Yuanyuan; Saleh, Muhammad G et al. (2018) Inhibitory motor dysfunction in parkinson's disease subtypes. J Magn Reson Imaging 47:1610-1615
Mikkelsen, Mark; Saleh, Muhammad G; Near, Jamie et al. (2018) Frequency and phase correction for multiplexed edited MRS of GABA and glutathione. Magn Reson Med 80:21-28
Mikkelsen, Mark; Wodka, Ericka L; Mostofsky, Stewart H et al. (2018) Autism spectrum disorder in the scope of tactile processing. Dev Cogn Neurosci 29:140-150
Gao, Fei; Yin, Xuntao; Edden, Richard A E et al. (2018) Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis. Hippocampus 28:813-823
Hermans, Lize; Leunissen, Inge; Pauwels, Lisa et al. (2018) Brain GABA Levels Are Associated with Inhibitory Control Deficits in Older Adults. J Neurosci 38:7844-7851
Deligiannidis, Kristina M; Fales, Christina L; Kroll-Desrosiers, Aimee R et al. (2018) Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic imaging and resonance study. Neuropsychopharmacology :
Oeltzschner, Georg; Snoussi, Karim; Puts, Nicolaas A et al. (2018) Effects of eddy currents on selective spectral editing experiments at 3T. J Magn Reson Imaging 47:673-681
Cao, Guanmei; Edden, Richard A E; Gao, Fei et al. (2018) Reduced GABA levels correlate with cognitive impairment in patients with relapsing-remitting multiple sclerosis. Eur Radiol 28:1140-1148

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