Nuclear medical imaging such as single-photon emission computed tomography (SPECT) and positron emission computed tomography (PET) have become important tools in pre-clinical and clinical imaging applications. A major task in developing a nuclear medical imaging camera is the electronics system. The problem is that such electronics requires a significant development effort beyond the capability of most research groups. While commercial PET and SPECT camera manufacturers have developed such electronics, they are typically optimized for specific products (and so are difficult to adapt and usually are proprietary (and so are not available to most researchers). Currently, research groups with sufficient resources are forced to independently develop their own customized electronics for specific projects. Research groups without sufficient resources or expertise are forced instead to depend on commercially available electronics with limited flexibility for handling high-performance detectors and limited access to source code for modification. Overall, this situation can lead to detector and camera design compromises that sacrifice performance, due to the difficulties of designing the electronics system. It also wastes the limited resources (funding, time, expertise, etc.) since researchers are working independently and duplicating efforts. In this project we propose to develop a flexible, scalable, and high-performance OpenPET electronics system with open availability to overcome these problems. While there are a tremendous number of variations, the relatively simple nature of the data ultimately collected implies that there can be a common set of requirements, which would allow us to develop OpenPET into a community resource that would resolve one of the major problems faced by developers of nuclear medical imaging cameras. Each gamma ray interaction is characterized by a small number of attributes, usually no more than a three-dimensional interaction position, a measure of the deposited energy, and an interaction time. Data are collected either as single interactions or coincident pairs, and only a small amount of ancillary information is needed (such as count rates, the position of an attenuation source, or a gating signal). The OpenPET design is largely driven by the need for flexibility, high performance and "open- source." We will achieve these needs by: (1) extensive use of field-programmable gate arrays (FPGAs) to provide highly programmable electronics, (2) utilizing waveform sampling in the electronics to make the signal processing more flexible and to achieve higher performance than conventional analog electronics circuitry, (3) having ready procurement of the system hardware from pre-arranged vendors, (4) having documentation and source code freely available, and (5) developing a user community that will pool their software and hardware enhancements. The ultimate goal is to provide a rich set of solution and enabling technology for the research community at large.

Public Health Relevance

One of the major development efforts in developing a nuclear medical imaging camera, namely positron emission computed tomograph (PET) or single-photon emission computed tomograph (SPECT), is the electronics system. The problem is such electronics requires a significant development effort and most developers of prototype cameras do not have the resources for this development. This proposal aims to resolve this problem by developing the necessary resources to build the needed electronics system, which will likely advance the development of advanced nuclear medical imaging cameras, and thus have a high impact on public health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB016104-01A1
Application #
8580533
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Sastre, Antonio
Project Start
2013-08-01
Project End
2017-05-31
Budget Start
2013-08-01
Budget End
2014-05-31
Support Year
1
Fiscal Year
2013
Total Cost
$816,687
Indirect Cost
$326,420
Name
Lawrence Berkeley National Laboratory
Department
Type
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720
Kim, H; Chen, C-T; Eclov, N et al. (2014) A New Time Calibration Method for Switched-capacitor-array-based Waveform Samplers. Nucl Instrum Methods Phys Res A 767:67-74