Edited magnetic resonance spectroscopy allows the non-invasive detection of low-concentration metabolites within the brain, such as the inhibitory neurotransmitter GABA and the redox compound glutathione (GSH). The signals of such metabolites are often overlapped in the MR spectrum, but a tailored spectral editing experiment can selectively retrieve signals of interest. Such ?edited? approaches generally focus on measuring a single metabolite (i.e. either GABA or GSH) in a single brain region; the main goal of this proposal is to develop Hadamard-edited experiments that detect GABA and GSH simultaneously, in a single acquisition. We will develop the Hadamard-encoded HERMES approach, and multi-voxel Hadamard editing, using the SHERPA and HERMES-SHERPA approaches. The resulting data acquisition, post- processing and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.

Public Health Relevance

Magnetic resonance spectroscopy measures the concentration of naturally occurring chemicals within the body using an MRI scanner to, often focusing on one particular chemical and location using ?edited? methods. This project will develop new experimental and data processing tools to allow simultaneous edited measurements of two key brain compoudnds, GABA and glutathione.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB023963-01
Application #
9286636
Study Section
Medical Imaging Study Section (MEDI)
Program Officer
Liu, Guoying
Project Start
2017-05-05
Project End
2021-01-31
Budget Start
2017-05-05
Budget End
2018-01-31
Support Year
1
Fiscal Year
2017
Total Cost
$381,417
Indirect Cost
$138,122
Name
Johns Hopkins University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Kurcyus, Katarzyna; Annac, Efsun; Hanning, Nina M et al. (2018) Opposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing. J Neurosci 38:9967-9976
Oeltzschner, Georg; Chan, Kimberly L; Saleh, Muhammad G et al. (2018) Hadamard editing of glutathione and macromolecule-suppressed GABA. NMR Biomed 31:
Gong, Tao; Xiang, Yuanyuan; Saleh, Muhammad G et al. (2018) Inhibitory motor dysfunction in parkinson's disease subtypes. J Magn Reson Imaging 47:1610-1615
Mikkelsen, Mark; Saleh, Muhammad G; Near, Jamie et al. (2018) Frequency and phase correction for multiplexed edited MRS of GABA and glutathione. Magn Reson Med 80:21-28
Oeltzschner, Georg; Snoussi, Karim; Puts, Nicolaas A et al. (2018) Effects of eddy currents on selective spectral editing experiments at 3T. J Magn Reson Imaging 47:673-681
Saleh, Muhammad G; Mikkelsen, Mark; Oeltzschner, Georg et al. (2018) Simultaneous editing of GABA and glutathione at 7T using semi-LASER localization. Magn Reson Med 80:474-479
Mikkelsen, Mark; Barker, Peter B; Bhattacharyya, Pallab K et al. (2017) Big GABA: Edited MR spectroscopy at 24 research sites. Neuroimage 159:32-45