Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES003830-08
Application #
3251550
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1988-08-01
Project End
1994-09-12
Budget Start
1994-06-01
Budget End
1994-09-12
Support Year
8
Fiscal Year
1994
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Geohagen, Brian C; Korsharskyy, Boris; Vydyanatha, Amaresh et al. (2018) Phloretin cytoprotection and toxicity. Chem Biol Interact 296:117-123
LoPachin, Richard M; Gavin, Terrence (2016) Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation. Free Radic Res 50:195-205
Geohagen, Brian C; Vydyanathan, Amaresh; Kosharskyy, Boleslav et al. (2016) Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity. J Pharmacol Exp Ther 357:476-86
Zhang, Lihai; Geohagen, Brian C; Gavin, Terrence et al. (2016) Joint toxic effects of the type-2 alkene electrophiles. Chem Biol Interact 254:198-206
Kosharskyy, Boleslav; Vydyanathan, Amaresh; Zhang, Lihai et al. (2015) 2-Acetylcyclopentanone, an enolate-forming 1,3-dicarbonyl compound, is cytoprotective in warm ischemia-reperfusion injury of rat liver. J Pharmacol Exp Ther 353:150-8
LoPachin, Richard M; Gavin, Terrence (2015) Protein adduct formation initiates acrolein-induced endothelial cell toxicity. Toxicol Sci 144:2-3
LoPachin, Richard M; Gavin, Terrence (2015) Toxic neuropathies: Mechanistic insights based on a chemical perspective. Neurosci Lett 596:78-83
LoPachin, Richard M; Gavin, Terrence (2014) Molecular mechanisms of aldehyde toxicity: a chemical perspective. Chem Res Toxicol 27:1081-91
Zhang, Lihai; Gavin, Terrence; Geohagen, Brian C et al. (2013) Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity. J Pharmacol Exp Ther 346:259-69
Martyniuk, Christopher J; Feswick, April; Fang, Bin et al. (2013) Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells. Toxicol Lett 219:279-87

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