Abstract

The overall objective of this project is to investigate the role(s) of sulfhydryl (SH) compounds in the cytotoxic effects of selenite. The investigators will determine the sensitivity of drug-resistant tumors to selenite in vivo using three alternative animal models: the growth of subcutaneous human ovarian and breast tumors and intraperitoneal ovarian tumors in athymic (nude) mice. They will also determine whether selenite can prevent the development of drug resistance in vitro in a population of drug-sensitive tumor cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES004087-09A1
Application #
2153550
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1986-06-15
Project End
1998-03-31
Budget Start
1995-04-01
Budget End
1996-03-31
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Rutgers University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901

  Publications

Caffrey, P B; Frenkel, G D (2000) Selenium compounds prevent the induction of drug resistance by cisplatin in human ovarian tumor xenografts in vivo. Cancer Chemother Pharmacol 46:74-8
Caffrey, P B; Zhu, M; Zhang, Y et al. (1999) Rapid development of glutathione-S-transferase-dependent drug resistance in vitro and its prevention by ethacrynic acid. Cancer Lett 136:47-52
Caffrey, P B; Zhang, Y; Frenkel, G D (1998) Rapid development of drug resistance in human ovarian tumor xenografts after a single treatment with melphalan in Vivo. Anticancer Res 18:3021-5
Zhu, M; Gong, Y; Frenkel, G D (1998) Studies on the mechanism of the selenite-induced decrease in cell attachment: effect of selenite on the levels of fibronectin receptor (alpha5beta1 integrin) mRNAs. Biol Trace Elem Res 62:123-34
Caffrey, P B; Frenkel, G D (1998) Treatment of human ovarian tumor xenografts with selenite prevents the melphalan-induced development of drug resistance. Anticancer Res 18:3017-20
Caffrey, P B; Zhu, M; Frenkel, G D (1998) Prevention of the development of melphalan resistance in vitro by selenite. Biol Trace Elem Res 65:187-95
Caffrey, P B; Frenkel, G D (1997) Sensitivity of melphalan-resistant tumors to selenite in vivo. Cancer Lett 121:177-80
Yan, L; Frenkel, G D (1994) Protein synthesis is not required for the inhibitory effect of selenite on cell colony formation and RNA synthesis. Biol Trace Elem Res 40:181-7
Yan, L; Frenkel, G D (1994) Effect of selenite on cell surface fibronectin receptor. Biol Trace Elem Res 46:79-89
Caffrey, P B; Frenkel, G D (1994) The development of drug resistance by tumor cells in vitro is accompanied by the development of sensitivity to selenite. Cancer Lett 81:59-65

Showing the most recent 10 out of 24 publications