Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006334-03
Application #
2155196
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1993-05-01
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Rubin, Robert L; Hermanson, Tracee M; Bedrick, Edward J et al. (2005) Effect of cigarette smoke on autoimmunity in murine and human systemic lupus erythematosus. Toxicol Sci 87:86-96
Rubin, Robert L; Hermanson, Tracee M (2005) Plasticity in the positive selection of T cells: affinity of the selecting antigen and IL-7 affect T cell responsiveness. Int Immunol 17:959-71
Rubin, Robert L (2005) Drug-induced lupus. Toxicology 209:135-47
Rubin, R L; Kretz-Rommel, A (2001) A nondeletional mechanism for central T-cell tolerance. Crit Rev Immunol 21:29-40
Rubin, R L; Kretz-Rommel, A (2001) Phagocyte-mediated oxidation in idiosyncratic adverse drug reactions. Curr Opin Hematol 8:34-40
Rubin, R L; Salomon, D R; Guerrero, R S (2001) Thymus function in drug-induced lupus. Lupus 10:795-801
Kretz-Rommel, A; Rubin, R L (2001) Early cellular events in systemic autoimmunity driven by chromatin-reactive T cells. Cell Immunol 208:125-36
Kretz-Rommel, A; Rubin, R L (2000) Disruption of positive selection of thymocytes causes autoimmunity. Nat Med 6:298-305
Rubin, R L; Kretz-Rommel, A (1999) Initiation of autoimmunity by a reactive metabolite of a lupus-inducing drug in the thymus. Environ Health Perspect 107 Suppl 5:803-6
Kretz-Rommel, A; Rubin, R L (1999) Persistence of autoreactive T cell drive is required to elicit anti-chromatin antibodies in a murine model of drug-induced lupus. J Immunol 162:813-20

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