Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES009392-05
Application #
6624514
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Heindel, Jerrold
Project Start
1999-02-01
Project End
2006-02-28
Budget Start
2003-03-01
Budget End
2004-02-29
Support Year
5
Fiscal Year
2003
Total Cost
$298,000
Indirect Cost
Name
Wayne State University
Department
Type
Organized Research Units
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Reiners Jr, John J; Kleinman, Miriam; Kessel, David et al. (2011) Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization. Free Radic Biol Med 50:281-94
Kessel, David; Vicente, M Graca H; Reiners Jr, John J (2006) Initiation of apoptosis and autophagy by photodynamic therapy. Lasers Surg Med 38:482-8
Caruso, Joseph A; Mathieu, Patricia A; Joiakim, Aby et al. (2006) Aryl hydrocarbon receptor modulation of tumor necrosis factor-alpha-induced apoptosis and lysosomal disruption in a hepatoma model that is caspase-8-independent. J Biol Chem 281:10954-67
Caruso, Joseph A; Reiners Jr, John J (2006) Proteolysis of HIP during apoptosis occurs within a region similar to the BID loop. Apoptosis 11:1877-85
Reiners Jr, John J; Kessel, David (2005) Susceptibility of myelomonocytic leukemia U937 cells to the induction of apoptosis by the non-peptidic Bcl-2 ligand HA14-1 is cell cycle phase-dependent. Cancer Lett 221:153-63
Caruso, Joseph A; Mathieu, Patricia A; Reiners Jr, John J (2005) Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy. Biochem J 392:325-34
Kessel, D; Castelli, M; Reiners, J J (2005) Ruthenium red-mediated suppression of Bcl-2 loss and Ca(2+) release initiated by photodamage to the endoplasmic reticulum: scavenging of reactive oxygen species. Cell Death Differ 12:502-11
Joiakim, Aby; Mathieu, Patricia A; Elliott, Althea A et al. (2004) Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome. Mol Pharmacol 66:936-47
Castelli, M; Reiners, J J; Kessel, D (2004) A mechanism for the proapoptotic activity of ursodeoxycholic acid: effects on Bcl-2 conformation. Cell Death Differ 11:906-14
Caruso, Joseph A; Mathieu, Patricia A; Joiakim, Aby et al. (2004) Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents. Mol Pharmacol 65:1016-28

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