The long term, goal of this research is to elucidate the cause(s) of Parkinson's Disease (PD) with a focus on environmental determinants. The investigators propose to investigate the relationship between PD and exposure to pesticides and other factors by conducting a nested case-control study in the Agricultural Health Study (AHS), using a 3:1 case-control ratio and employing classical methods for multi-variate analysis. There are 2 primary aims.
Aim 1 will test the hypothesis that pesticide exposure increases PD risk using self-report (life history) and direct (blood, dust) measurements.
Aim 2 will test the hypothesis that other (nonpesticide) chemical exposure increases PD risk, using a job-task-based occupational history, and blood testing. Three secondary aims: 1) will test the hypothesis that the soil pathogen Nocardia asteroides causes PD using a battery of assays in blood, soil and dust (aim 3); 2) will assess the role of specific lifestyle and health factors previously reported to alter PD risk (aim 4); and, 3) will assess the effect of specific polymorphisms of xenobiotic metabolizing, genes previously associated with PD on disease risk (aim 5). The studies proposed take full advantage of the AHS, a unique, prospectively studied cohort. The investigators believe that this work could provide a critical and dramatic next step in furthering our knowledge of environmental determinants of PD, and thereby take us closer to our goal of finding its cause(s).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES010803-03
Application #
6518199
Study Section
Special Emphasis Panel (ZES1-LKB-C (D1))
Program Officer
Lawler, Cindy P
Project Start
2000-09-01
Project End
2005-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
3
Fiscal Year
2002
Total Cost
$735,925
Indirect Cost
Name
Parkinson's Institute
Department
Type
DUNS #
614259935
City
Sunnyvale
State
CA
Country
United States
Zip Code
94085
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Kamel, Freya; Goldman, Samuel M; Umbach, David M et al. (2014) Dietary fat intake, pesticide use, and Parkinson's disease. Parkinsonism Relat Disord 20:82-7
Goldman, Samuel M; Kamel, Freya; Ross, G Webster et al. (2014) Peptidoglycan recognition protein genes and risk of Parkinson's disease. Mov Disord 29:1171-80
McGuire, V; Van Den Eeden, S K; Tanner, C M et al. (2011) Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium. J Neurol Sci 307:22-9
Popat, R A; Van Den Eeden, S K; Tanner, C M et al. (2011) Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease. Eur J Neurol 18:756-65
Kamel, F; Tanner, Cm; Umbach, Dm et al. (2007) Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am J Epidemiol 165:364-74
Chade, A R; Kasten, M; Tanner, C M (2006) Nongenetic causes of Parkinson's disease. J Neural Transm Suppl :147-51
Sobel, N; Thomason, M E; Stappen, I et al. (2001) An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease. Proc Natl Acad Sci U S A 98:4154-9