We propose a CBPR study of the relationship between air pollution gradients and health effects in individuals living next to major highways. There is evidence that (1) people living close to highways experience significantly elevated exposures to constituents of motor vehicle exhaust including ultrafine particles (UFP;0.01-1 microns) and black carbon;and (2) that motor vehicle pollution is associated with cardiac mortality and morbidity in adults, and asthma and reduced lung function in children. C-reactive protein (CRP), an inflammatory marker of risk for cardiac illness, has been shown to increase in response to changes in particulate exposure, making it a viable indicator of the potential impact on cardiac health. Our core study involves measuring 5 traffic-related pollutants (i.e., UFP, PM2.5, NOx, CO, black carbon, particulate PAH) in 6 neighborhoods within 400 meters of highways through in the Boston area. A background site >1000 m from highways will also be monitored. We will compete a scientific survey of residents living in the neighborhoods to determine pediatric asthma prevalence. We will determine the time residents spent within the near highway zone currently and rigorously measure highway pollution gradients in the neighborhoods. We will document exposures at work, school and while commuting. For a subset of non-smoking households we will obtain pulmonary function tests from children and analyze multiple blood samples per person from adults for CRP and fibrinogen. Our study will be (1) the first to test associations between highway pollution gradients and biological markers of health, (2) the first CBPR study of highway pollution, and (3) the most comprehensive collection of data on time spent in the exposure zone and many confounders and effect modifiers. We will conduct bivariate and regression analyses and have developed preliminary mathematical models that frame our approach to analyzing the large set of data. Our team consists of faculty at Tufts University and 6 co- investigators from community organizations that are concerned about the impact of highways on the health of residents in their communities. We will train and hire field staff from the communities and have an advisory board. We will link community participation to the science through participation in our steering committee and through our advisory board. Our study is designed to report useful information locally as well as influence pressing national policy needs. This proposal was developed to actively involve communities living very near to major highways in scientific research on the health effects of pollutant gradients coming off the highways (to about 200 meters). The study emphasizes the role of ultrafine particles on development of asthma in children, reduction of lung function in non-asthmatic children and increases in markers of inflammation and heart disease risk (C-reactive protein) in adults.

Public Health Relevance

This proposal was developed to actively involve communities living very near to major highways in scientific research on the health effects of pollutant gradients coming off the highways (to about 200 meters). The study emphasizes the role of ultrafine particles on development of asthma in children, reduction of lung function in non-asthmatic children and increases in markers of inflammation and heart disease risk (C-reactive protein) in adults.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES015462-05
Application #
8241661
Study Section
Special Emphasis Panel (ZRG1-HOP-S (52))
Program Officer
Dilworth, Caroline H
Project Start
2008-06-13
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2012
Total Cost
$339,910
Indirect Cost
$124,664
Name
Tufts University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Lane, Kevin J; Levy, Jonathan I; Scammell, Madeleine K et al. (2016) Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers. Environ Int 92-93:173-82
Patton, Allison P; Zamore, Wig; Naumova, Elena N et al. (2015) Transferability and generalizability of regression models of ultrafine particles in urban neighborhoods in the Boston area. Environ Sci Technol 49:6051-60
Laws, M Barton; Yeh, Yating; Reisner, Ellin et al. (2015) Gender, Ethnicity and Environmental Risk Perception Revisited: The Importance of Residential Location. J Community Health 40:948-55
Brugge, Doug; Patton, Allison P; Bob, Alex et al. (2015) Developing Community-Level Policy and Practice to Reduce Traffic-Related Air Pollution Exposure. Environ Justice 8:95-104
Padró-Martínez, Luz T; Owusu, Emmanuel; Reisner, Ellen et al. (2015) A Randomized Cross-over Air Filtration Intervention Trial for Reducing Cardiovascular Health Risks in Residents of Public Housing near a Highway. Int J Environ Res Public Health 12:7814-38
Lane, Kevin J; Levy, Jonathan I; Scammell, Madeleine Kangsen et al. (2015) Effect of time-activity adjustment on exposure assessment for traffic-related ultrafine particles. J Expo Sci Environ Epidemiol 25:506-16
Fuller, Christina H; Williams, Paige L; Mittleman, Murray A et al. (2015) Response of biomarkers of inflammation and coagulation to short-term changes in central site, local, and predicted particle number concentrations. Ann Epidemiol 25:505-11
Rioux, Christine L; Tucker, Katherine L; Brugge, Doug et al. (2015) Medication type modifies inflammatory response to traffic exposure in a population with type 2 diabetes. Environ Pollut 202:58-65
Chung, Mei; Wang, Ding Ding; Rizzo, Amanda M et al. (2015) Association of PNC, BC, and PM2.5 measured at a central monitoring site with blood pressure in a predominantly near highway population. Int J Environ Res Public Health 12:2765-80
Patton, Allison P; Perkins, Jessica; Zamore, Wig et al. (2014) Spatial and temporal differences in traffic-related air pollution in three urban neighborhoods near an interstate highway. Atmos Environ (1994) 99:309-321

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