We propose a CBPR study of the relationship between air pollution gradients and health effects in individuals living next to major highways. There is evidence that (1) people living close to highways experience significantly elevated exposures to constituents of motor vehicle exhaust including ultrafine particles (UFP;0.01-1 microns) and black carbon;and (2) that motor vehicle pollution is associated with cardiac mortality and morbidity in adults, and asthma and reduced lung function in children. C-reactive protein (CRP), an inflammatory marker of risk for cardiac illness, has been shown to increase in response to changes in particulate exposure, making it a viable indicator of the potential impact on cardiac health. Our core study involves measuring 5 traffic-related pollutants (i.e., UFP, PM2.5, NOx, CO, black carbon, particulate PAH) in 6 neighborhoods within 400 meters of highways through in the Boston area. A background site >1000 m from highways will also be monitored. We will compete a scientific survey of residents living in the neighborhoods to determine pediatric asthma prevalence. We will determine the time residents spent within the near highway zone currently and rigorously measure highway pollution gradients in the neighborhoods. We will document exposures at work, school and while commuting. For a subset of non-smoking households we will obtain pulmonary function tests from children and analyze multiple blood samples per person from adults for CRP and fibrinogen. Our study will be (1) the first to test associations between highway pollution gradients and biological markers of health, (2) the first CBPR study of highway pollution, and (3) the most comprehensive collection of data on time spent in the exposure zone and many confounders and effect modifiers. We will conduct bivariate and regression analyses and have developed preliminary mathematical models that frame our approach to analyzing the large set of data. Our team consists of faculty at Tufts University and 6 co- investigators from community organizations that are concerned about the impact of highways on the health of residents in their communities. We will train and hire field staff from the communities and have an advisory board. We will link community participation to the science through participation in our steering committee and through our advisory board. Our study is designed to report useful information locally as well as influence pressing national policy needs. This proposal was developed to actively involve communities living very near to major highways in scientific research on the health effects of pollutant gradients coming off the highways (to about 200 meters). The study emphasizes the role of ultrafine particles on development of asthma in children, reduction of lung function in non-asthmatic children and increases in markers of inflammation and heart disease risk (C-reactive protein) in adults.

Public Health Relevance

This proposal was developed to actively involve communities living very near to major highways in scientific research on the health effects of pollutant gradients coming off the highways (to about 200 meters). The study emphasizes the role of ultrafine particles on development of asthma in children, reduction of lung function in non-asthmatic children and increases in markers of inflammation and heart disease risk (C-reactive protein) in adults.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES015462-05
Application #
8241661
Study Section
Special Emphasis Panel (ZRG1-HOP-S (52))
Program Officer
Dilworth, Caroline H
Project Start
2008-06-13
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2012
Total Cost
$339,910
Indirect Cost
$124,664
Name
Tufts University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Patton, Allison P; Perkins, Jessica; Zamore, Wig et al. (2014) Spatial and temporal differences in traffic-related air pollution in three urban neighborhoods near an interstate highway. Atmos Environ (1994) 99:309-321
Corlin, Laura; Woodin, Mark; Thanikachalam, Mohan et al. (2014) Evidence for the healthy immigrant effect in older Chinese immigrants: a cross-sectional study. BMC Public Health 14:603
Wu, Chih-Da; MacNaughton, Piers; Melly, Steve et al. (2014) Mapping the vertical distribution of population and particulate air pollution in a near-highway urban neighborhood: implications for exposure assessment. J Expo Sci Environ Epidemiol 24:297-304
Patton, Allison P; Collins, Caitlin; Naumova, Elena N et al. (2014) An hourly regression model for ultrafine particles in a near-highway urban area. Environ Sci Technol 48:3272-80
Lane, Kevin J; Kangsen Scammell, Madeleine; Levy, Jonathan I et al. (2013) Positional error and time-activity patterns in near-highway proximity studies: an exposure misclassification analysis. Environ Health 12:75
Brugge, Doug; Reisner, Ellin; Padro-Martinez, Luz T et al. (2013) In-home air filtration for improving cardiovascular health: lessons from a CBPR study in public housing. Prog Community Health Partnersh 7:49-56
Fuller, Christina H; Patton, Allison P; Lane, Kevin et al. (2013) A community participatory study of cardiovascular health and exposure to near-highway air pollution: study design and methods. Rev Environ Health 28:21-35
Brugge, Doug; Lane, Kevin J; Stewart, Andrea et al. (2013) Highway proximity associations with blood markers of inflammation: evidence for a role for IL-1?. J Toxicol Environ Health A 76:201-5
Brugge, Doug; Lane, Kevin; Padro-Martinez, Luz T et al. (2013) Highway proximity associated with cardiovascular disease risk: the influence of individual-level confounders and exposure misclassification. Environ Health 12:84
Fuller, Christina H; Brugge, Doug; Williams, Paige L et al. (2013) Indoor and outdoor measurements of particle number concentration in near-highway homes. J Expo Sci Environ Epidemiol 23:506-12

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