In this proposal, we will investigate whether environmental factors during pregnancy are related to the likelihood that the offspring will be diagnosed with autism. These factors include infections, immune abnormalities, hormones, and smoking.
We aim to address these questions in pregnancies of 1,000 autism cases and 1,000 healthy children using maternal serum samples that were drawn and stored in nearly all pregnancies in Finland from 1987-2007. Children with autism and healthy children matched to the cases on sex, date of birth, birth place and residence in Finland will be identified from detailed national databases that contain diagnoses on nearly all cases of autism in Finland. The serum samples of mothers of autism cases and mothers of healthy controls will be analyzed for these environmental factors. We shall also test whether these maternal environmental factors during pregnancy are related to other pregnancy and birth complications and to abnormalities in growth of the child's head over the first few years of life, prior to the onset of autism. In previous studies, increased head size has been observed in children with autism and this may also be related to development of the illness. For this purpose, we will make use of other large national databases available in nearly all births in Finland. Moreover, we will test whether there are differences in susceptibility to these environmental factors between boys and girls with autism. This study will lay the groundwork for future projects in which we will increase the sample size further, to as many as 5,000 cases of autism, expand the types of risk factors and infant/childhood developmental measures examined, compare effects of risk factors between different subtypes of autism, and assess gene-environment interactions. This research has the potential to result in a better understanding of the different causes of autism and different developmental pathways that can lead to the illness. The discovery of these causes can lead to prevention of cases of autism by improved prenatal care and to the identification of children who are at risk of developing autism.

Public Health Relevance

This work has high public health significance. The identification of prenatal etiologies of autism, and their relationship with other developmental antecedents, has the potential to lead to the eradication of a considerable portion of autism cases through implementable public health measures, such as the administration of influenza vaccination, the prevention of sexually transmitted diseases, thyroid hormone supplementation, and anti-smoking campaigns targeted to pregnant women. Moreover, the research described in this proposal has the potential to facilitate the identification of children at risk for autism and to pathogenic mechanisms by which these early life exposures operate to increase risk for this disorder, which can lead to new modalities of prevention and therapeutic intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES019004-02
Application #
7941826
Study Section
Special Emphasis Panel (ZMH1-ERB-S (A1))
Program Officer
Lawler, Cindy P
Project Start
2009-09-28
Project End
2012-07-31
Budget Start
2010-08-01
Budget End
2012-07-31
Support Year
2
Fiscal Year
2010
Total Cost
$408,838
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Timonen-Soivio, Laura; Vanhala, Raija; Malm, Heli et al. (2016) Brief Report: Syndromes in Autistic Children in a Finnish Birth Cohort. J Autism Dev Disord 46:2780-4
Brown, Alan S; Surcel, Heljä-Marja; Hinkka-Yli-Salomäki, Susanna et al. (2015) Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. Prog Neuropsychopharmacol Biol Psychiatry 57:86-92
Lehti, Venla; Cheslack-Postava, Keely; Gissler, Mika et al. (2015) Parental migration and Asperger's syndrome. Eur Child Adolesc Psychiatry 24:941-8
Timonen-Soivio, Laura; Sourander, Andre; Malm, Heli et al. (2015) The association between autism spectrum disorders and congenital anomalies by organ systems in a Finnish national birth cohort. J Autism Dev Disord 45:3195-203
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Timonen-Soivio, Laura; Vanhala, Raija; Malm, Heli et al. (2015) The association between congenital anomalies and autism spectrum disorders in a Finnish national birth cohort. Dev Med Child Neurol 57:75-80
McKeague, Ian W; Brown, Alan S; Bao, Yuanyuan et al. (2015) Autism with intellectual disability related to dynamics of head circumference growth during early infancy. Biol Psychiatry 77:833-40
Cheslack-Postava, Keely; Suominen, Auli; Jokiranta, Elina et al. (2014) Increased risk of autism spectrum disorders at short and long interpregnancy intervals in Finland. J Am Acad Child Adolesc Psychiatry 53:1074-81.e4
Hinkka-Yli-Salomäki, Susanna; Banerjee, P Nina; Gissler, Mika et al. (2014) The incidence of diagnosed autism spectrum disorders in Finland. Nord J Psychiatry 68:472-80
Jokiranta, Elina; Sourander, Andre; Suominen, Auli et al. (2014) Epilepsy among children and adolescents with autism spectrum disorders: a population-based study. J Autism Dev Disord 44:2547-57

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