Air pollution increases the risk of acute cardiovascular events. Whether it contributes to the risk of hypertension and diabetes, chronic predisposing conditions to cardiovascular disease, is unknown. Hypertension and type 2 diabetes occur much more commonly among U.S. black women than white women, a discrepancy only partly explained by known risk factors. U.S. black women tend to live in neighborhoods with more air pollution than their white counterparts, regardless of socioeconomic status. With state-of-the-art methods, we propose to test the hypotheses that exposure to air pollution increases the risks of incident hypertension and type 2 diabetes in African American women. We will focus on particulate matter of d2.5

Public Health Relevance

The proposed study will evaluate whether exposure to air pollution increases the risks of incident hypertension and type 2 diabetes in a cohort of 59,000 African American women from across the U.S. The study is of immense public health importance given the high prevalence of hypertension and diabetes, the disparity in the incidence between black and white women, and the ubiquity of exposure to air pollution. Positive findings will inform public policy on air quality regulation, illuminate causes of racial disparities in the incidence of hypertension, and diabetes provide pivotal insight into a novel pathway whereby air pollution causes cardiovascular events, and motivate additional research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES019573-02
Application #
8312504
Study Section
Kidney, Nutrition, Obesity and Diabetes (KNOD)
Program Officer
Dilworth, Caroline H
Project Start
2011-08-01
Project End
2016-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
2
Fiscal Year
2012
Total Cost
$511,274
Indirect Cost
$47,327
Name
Boston University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Jerrett, Michael; Turner, Michelle C; Beckerman, Bernardo S et al. (2017) Comparing the Health Effects of Ambient Particulate Matter Estimated Using Ground-Based versus Remote Sensing Exposure Estimates. Environ Health Perspect 125:552-559
Coogan, Patricia F; White, Laura F; Yu, Jeffrey et al. (2017) Long-Term Exposure to NO2 and Ozone and Hypertension Incidence in the Black Women's Health Study. Am J Hypertens 30:367-372
Jerrett, Michael; Brook, Robert; White, Laura F et al. (2017) Ambient ozone and incident diabetes: A prospective analysis in a large cohort of African American women. Environ Int 102:42-47
White, Laura F; Yu, Jeffrey; Jerrett, Michael et al. (2016) Temporal aspects of air pollutant measures in epidemiologic analysis: a simulation study. Sci Rep 6:19691
Stieb, David M; Chen, Li; Hystad, Perry et al. (2016) A national study of the association between traffic-related air pollution and adverse pregnancy outcomes in Canada, 1999-2008. Environ Res 148:513-526
Coogan, Patricia F; White, Laura F; Yu, Jeffrey et al. (2016) PM2.5 and Diabetes and Hypertension Incidence in the Black Women's Health Study. Epidemiology 27:202-10
White, Laura F; Jerrett, Michael; Yu, Jeffrey et al. (2016) Ambient Air Pollution and 16-Year Weight Change in African-American Women. Am J Prev Med 51:e99-e105
Stieb, David M; Chen, Li; Beckerman, Bernardo S et al. (2016) Associations of Pregnancy Outcomes and PM2.5 in a National Canadian Study. Environ Health Perspect 124:243-9
Coogan, Patricia F; White, Laura F; Yu, Jeffrey et al. (2016) Long term exposure to NO2 and diabetes incidence in the Black Women's Health Study. Environ Res 148:360-366
Pope 3rd, C Arden; Turner, Michelle C; Burnett, Richard T et al. (2015) Relationships between fine particulate air pollution, cardiometabolic disorders, and cardiovascular mortality. Circ Res 116:108-15

Showing the most recent 10 out of 13 publications