Preterm delivery, low birth weight and small for gestational age (SGA) are major causes of infant mortality and severe morbidity in the U.S. For African Americans, these risks are nearly doubled. Several studies have implicated air pollution, especially particulate matter <2.5mm (PM2.5) as a risk factor for adverse birth outcomes. A challenge in this research is that particles vary widely in chemical composition by region and season. Due to lack of scientific evidence on which types of particles are most harmful, particles are regulated by size. We will investigate two aspects of the chemical composition of particles: 1) levels of individual PM2.5 chemical components (e.g., nickel);and 2) levels of PM2.5 from specific sources (e.g. oil combustion), to investigate the relationship between exposure to specific types of particles and birth outcomes. We obtained filters from 8 CT and MA monitoring sites that were used to measure PM2.5 total mass. We will analyze these filters to determine levels of 49 chemical components. This chemical component data will be used in source apportionment modeling to estimate PM2.5 from specific sources (e.g. motor vehicles). Our primary outcomes will be birth weight (continuous), low birth weight <2500 gm, very low birth weight <1500 gm, preterm birth <37 wks, very preterm birth <32 wks, and small for gestational age (<10th percentile weight for gestational age), using CT and MA birth certificate data for births (2001-2006) within 30 km of the monitoring sites (N=213,000). Associations will be assessed between birth outcomes and PM2.5 chemical components (Aim 1) and between birth outcomes and the levels of PM2.5 from particular sources (Aim 2).
In Aim 3 we will examine traffic PM2.5 with three exposure methods: 1) the chemical component most associated with traffic from Aim 1;2) traffic PM2.5 levels from Aim 2;and 3) traffic-related air pollution estimated through a GIS traffic model. In our preliminary studies, risk of low birth weight increased 8-13% per interquartile range (IQR) increase in exposure to specific PM2.5 components. We will have >90% power to detect a 10% increase in risk of any outcome (including very low birth weight, prevalence 1.5%) associated with an IQR change exposure to a specific PM2.5 component or PM2.5 source. Associations will be investigated in interaction models to test whether effects differ by race. Findings from this study will identify the components or sources of PM2.5 with the greatest impact on birth outcomes and could lead to interventions targeted at the sources most toxic to infant health.

Public Health Relevance

We are currently investigating the effects of PM2.5 (total particle mass) on adverse birth outcomes: preterm delivery, low birth weight and intrauterine growth restriction. In this application, we propose to determine the chemical composition of the particles and the sources of PM2.5 to investigate the relationship between exposure to specific types of particles and birth outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES019587-03
Application #
8449746
Study Section
Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section (IRAP)
Program Officer
Gray, Kimberly A
Project Start
2011-07-18
Project End
2016-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
3
Fiscal Year
2013
Total Cost
$553,347
Indirect Cost
$191,677
Name
Yale University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Bell, Michelle L; Zanobetti, Antonella; Dominici, Francesca (2014) Who is more affected by ozone pollution? A systematic review and meta-analysis. Am J Epidemiol 180:15-28
Hyder, Ayaz; Lee, Hyung Joo; Ebisu, Keita et al. (2014) PM2.5 exposure and birth outcomes: use of satellite- and monitor-based data. Epidemiology 25:58-67
Pereira, Gavin; Bell, Michelle L; Lee, Hyung Joo et al. (2014) Sources of fine particulate matter and risk of preterm birth in Connecticut, 2000-2006: a longitudinal study. Environ Health Perspect 122:1117-22
Pereira, Gavin; Bell, Michelle L; Belanger, Kathleen et al. (2014) Fine particulate matter and risk of preterm birth and pre-labor rupture of membranes in Perth, Western Australia 1997-2007: a longitudinal study. Environ Int 73:143-9
Bell, Michelle L; Ebisu, Keita; Leaderer, Brian P et al. (2014) Associations of PMýýý.ýýý constituents and sources with hospital admissions: analysis of four counties in Connecticut and Massachusetts (USA) for persons ýýý 65 years of age. Environ Health Perspect 122:138-44
Pereira, Gavin; Belanger, Kathleen; Ebisu, Keita et al. (2014) Fine particulate matter and risk of preterm birth in Connecticut in 2000-2006: a longitudinal study. Am J Epidemiol 179:67-74
Anderson, G Brooke; Krall, Jenna R; Peng, Roger D et al. (2013) The authors reply. Am J Epidemiol 177:1461-2
Bell, Michelle L; Zanobetti, Antonella; Dominici, Francesca (2013) Evidence on vulnerability and susceptibility to health risks associated with short-term exposure to particulate matter: a systematic review and meta-analysis. Am J Epidemiol 178:865-76
Anderson, G Brooke; Bell, Michelle L; Peng, Roger D (2013) Methods to calculate the heat index as an exposure metric in environmental health research. Environ Health Perspect 121:1111-9
Krall, Jenna R; Anderson, G Brooke; Dominici, Francesca et al. (2013) Short-term exposure to particulate matter constituents and mortality in a national study of U.S. urban communities. Environ Health Perspect 121:1148-53

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