The proposed study will address the hypothesis that exposure to traffic-related air pollution (TRAP) during critical periods of brain development is significantly associated with altered neurobehavior including deficits in cognition, attention, memory, executive function, global intelligence, neuromotor function, behavioral regulation, and altered brain anatomy and physiology. Exposure to environmental neurotoxicants prenatally and during early childhood has been associated with neurobehavioral deficits and altered brain structure. Recent toxicological evidence suggests that TRAP, a complex mixture of metals, elemental and organic carbon, polycyclic aromatic hydrocarbons, and fine and ultrafine particulate matter, is capable of inducing neuroinflammation and translocation across the blood-brain barrier resulting in direct exposure to the brain.
The aims of this study are to determine if children exposed to increased levels of TRAP during early stages of brain development have neurobehavioral deficits in childhood and to assess the physiologic impact of TRAP exposure on brain structure, organization, and function. The Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a prospective cohort study, provides an extraordinary opportunity to accomplish these aims. The CCAAPS cohort was recruited to examine the association between traffic exhaust and the development of allergic disease and asthma. Children enrolled in CCAAPS must have resided either less than 400 m or greater than 1500 m from a major highway at the time of their birth. TRAP exposure during early childhood has been characterized using ambient air monitoring and spatial models. Clinical health assessments, biomarkers, health questionnaires, and addresses of all home, daycare, and school locations have been collected at ages 1-4 and 7. The proposed study is innovative as it exploits all of the collected health, air monitoring, and modeling data and extends the focus of the CCAAPS cohort to examine the impact of early childhood TRAP exposure on neurobehavior and neuroimaging outcomes. A carefully selected battery of valid and reliable tests will be administered at age 11-12 to assess neurobehavioral development. Another unique aspect is the proposed nested study of children with high and low exposure to TRAP during early childhood to assess the physiologic impact of TRAP on the developing brain using quantitative magnetic resonance imaging (MRI). The anticipated results will address a significant gap in scientific knowledge of the potential neurotoxicity of a ubiquitous environmental exposure with far-reaching consequences for future studies and public health.
The association between exposure to traffic-related air pollution (TRAP) during early childhood and neurobehavioral and neuroimaging outcomes has not been thoroughly examined. The objective of the proposed study is to determine if children exposed to increased levels of TRAP during critical time periods of brain development have altered neurobehavior in childhood as measured by a battery of valid and reliable tests and to assess the physiologic impact of TRAP exposure on brain structure, organization, and function using quantitative magnetic resonance imaging (MRI). These results will fill important gaps in current scientific knowledge related to the relationship between TRAP exposure and neurobehavior and central nervous system effects.
|Biagini Myers, Jocelyn M; Schauberger, Eric; He, Hua et al. (2018) A Pediatric Asthma Risk Score to better predict asthma development in young children. J Allergy Clin Immunol :|
|Perez Ramirez, Leilanie; Wendroth, Heepke; Martin, Lisa J et al. (2018) High number of early respiratory infections in association with allergic sensitization to mold promotes childhood asthma. J Allergy Clin Immunol 141:1921-1924.e4|
|Sears, Clara G; Braun, Joseph M; Ryan, Patrick H et al. (2018) The association of traffic-related air and noise pollution with maternal blood pressure and hypertensive disorders of pregnancy in the HOME study cohort. Environ Int 121:574-581|
|Madzia, Juliana; Ryan, Patrick; Yolton, Kimberly et al. (2018) Residential Greenspace Association with Childhood Behavioral Outcomes. J Pediatr :|
|Zhang, Zhonghua; Biagini Myers, Jocelyn M; Brandt, Eric B et al. (2017) ?-Glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant TH2/TH17 responses. J Allergy Clin Immunol 139:54-65.e8|
|Brokamp, Cole; Jandarov, Roman; Rao, M B et al. (2017) Exposure assessment models for elemental components of particulate matter in an urban environment: A comparison of regression and random forest approaches. Atmos Environ (1994) 151:1-11|
|Johansson, Elisabet; Biagini Myers, Jocelyn M; Martin, Lisa J et al. (2017) KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis. J Allergy Clin Immunol 140:595-598.e5|
|Brokamp, Cole; LeMasters, Grace K; Ryan, Patrick H (2016) Residential mobility impacts exposure assessment and community socioeconomic characteristics in longitudinal epidemiology studies. J Expo Sci Environ Epidemiol 26:428-34|
|Ji, Hong; Biagini Myers, Jocelyn M; Brandt, Eric B et al. (2016) Air pollution, epigenetics, and asthma. Allergy Asthma Clin Immunol 12:51|
|Nanda, Maya K; LeMasters, Grace K; Levin, Linda et al. (2016) Allergic Diseases and Internalizing Behaviors in Early Childhood. Pediatrics 137:|
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