Polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl chemicals (PFCs, including perfluorooctane sulfonic acid [PFOS] and perfluorooctanoic acid [PFOA]) are persistent organic chemicals that were introduced several decades ago. Animal studies and limited human studies of PBDEs and PFCs have found evidence for developmental neurotoxicity in children, including thyroid hormone disruption, hyperactivity, delay in neuromotor maturation, and impaired cognition. Although these chemicals are being phased out, humans will still be exposed to PBDEs and PFCs in the environment for decades because these compounds were widely used as flame retardants and surfactants in consumer products. To address the potential adverse health risks of PBDEs and PFCs on fetal, infant, and child neurobehavioral development, the investigators will systematically examine their associations with thyroid function, cognition, learning and memory, motor skills, attention and executive function, and behavior from age 1 to 8 years. The long-term goal is to quantify the roles of PBDE and PFC exposures on child neurobehavior and to inform future prevention efforts. The three specific aims are to: 1) investigate the associations between prenatal and postnatal exposures to PBDEs and thyroid hormones and child neurobehavior;2) examine the associations between prenatal and postnatal exposures to PFCs and thyroid hormones and child neurobehavior;and 3) assess the environmental exposure to PBDEs through transplacental and lactational routes and indoor dust in children. The investigators will test these associations in the Health Outcomes and Measures of the Environment (HOME) Study, an ongoing NIEHS-funded longitudinal birth cohort of 398 women and their children with current follow-up to 5 years. The investigators will extend the cohort to include an age 8 follow-up clinical visit with comprehensive neurobehavior assessments. The investigators will examine the PBDE and PFC exposures at different developmental stages (in utero at 16 weeks of gestation, ages 3, 5, and 8 years) and child neurobehavior measured at 1, 2, 3, 4, 5, and 8 years using stored serum samples. This longitudinal study will allow the investigators to determine the dose response, windows of susceptibility, and persistence of the association. We will also examine the contribution of PBDE exposures from house dust in a subset of children who have complete sample collection of maternal serum and child serum at 1, 2, and 3 years, along with extensive measures of mouthing behaviors. This research is closely related to the NIH mission to investigate prevalent environmental toxicants and children's neurodevelopment.

Public Health Relevance

This proposed project will examine two groups of persistent organic chemicals for their associations with adverse effects in child neurobehavior: polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl chemicals (PFCs, including perfluorooctane sulfonic acid [PFOS] and perfluorooctanoic acid [PFOA]). The research project will provide novel information to the public about the developmental neurotoxicity of these chemicals. It will also generate new data regarding PBDEs'exposure routes to inform future prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES020349-04
Application #
8668058
Study Section
Special Emphasis Panel (ZRG1-PSE-K (03))
Program Officer
Gray, Kimberly A
Project Start
2011-08-23
Project End
2016-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
4
Fiscal Year
2014
Total Cost
$549,777
Indirect Cost
$109,884
Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
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Braun, Joseph M; Chen, Aimin; Romano, Megan E et al. (2016) Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study. Obesity (Silver Spring) 24:231-7
Vuong, Ann M; Braun, Joseph M; Sjödin, Andreas et al. (2016) Prenatal Polybrominated Diphenyl Ether Exposure and Body Mass Index in Children Up To 8 Years of Age. Environ Health Perspect 124:1891-1897
Braun, Joseph M; Bellinger, David C; Hauser, Russ et al. (2016) Prenatal phthalate, triclosan, and bisphenol A exposures and child visual-spatial abilities. Neurotoxicology 58:75-83
Vuong, Ann M; Braun, Joseph M; Yolton, Kimberly et al. (2016) Prenatal and postnatal polybrominated diphenyl ether exposure and visual spatial abilities in children. Environ Res 153:83-92
Khalil, Naila; Chen, Aimin; Lee, Miryoung et al. (2016) Association of Perfluoroalkyl Substances, Bone Mineral Density, and Osteoporosis in the U.S. Population in NHANES 2009-2010. Environ Health Perspect 124:81-7
Shoaff, Jessica R; Romano, Megan E; Yolton, Kimberly et al. (2016) Prenatal phthalate exposure and infant size at birth and gestational duration. Environ Res 150:52-8
Romano, Megan E; Xu, Yingying; Calafat, Antonia M et al. (2016) Maternal serum perfluoroalkyl substances during pregnancy and duration of breastfeeding. Environ Res 149:239-46
Moore, Elizabeth; Blatt, Kaitlin; Chen, Aimin et al. (2016) Factors Associated with Smoking Cessation in Pregnancy. Am J Perinatol 33:560-8
Percy, Zana; Xu, Yingying; Sucharew, Heidi et al. (2016) Gestational exposure to phthalates and gender-related play behaviors in 8-year-old children: an observational study. Environ Health 15:87

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