The expanding use of engineered nanomaterials (NM) in consumer products and technological applications has spurred environmental and consumer health and safety (H&S) concerns. This project investigates the question of NM skin exposure. We take a systematic approach to quantify effect on NM composition, charge, size on penetration through skin exposed to acute and chronic levels of ultraviolet radiation. Under conditions that NM penetrate skin we will characterize their association with epidermal cells, including antigen presenting cells to establish this as a mechanism of systemic transport. We will determine if and how NM may impact UVB induced immunosuppression and allergic contact hypersensitivity. Finally, we will determine if measuring inside-out water loss from skin is a viable means to assess outside-in NM penetration risk. This project will produce a concise body of work that will aid in assessing risk factors associated with unintentional NM skin exposure and discover novel mechanisms by which NM may impact skin immune function.

Public Health Relevance

The expanding use of engineered nanomaterials (NM) in consumer products and technological applications has spurred environmental and consumer health and safety (H&S) concerns. This project investigates the question of NM contact on ultraviolet radiation exposed skin.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES021492-02
Application #
8481550
Study Section
Nanotechnology Study Section (NANO)
Program Officer
Nadadur, Srikanth
Project Start
2012-06-05
Project End
2017-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
2
Fiscal Year
2013
Total Cost
$340,673
Indirect Cost
$120,173
Name
University of Rochester
Department
Dermatology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Jatana, Samreen; DeLouise, Lisa A (2014) Understanding engineered nanomaterial skin interactions and the modulatory effects of ultraviolet radiation skin exposure. Wiley Interdiscip Rev Nanomed Nanobiotechnol 6:61-79