The expanding use of engineered nanomaterials (NM) in consumer products and technological applications has spurred environmental and consumer health and safety (H&S) concerns. This project investigates the question of NM skin exposure. We take a systematic approach to quantify effect on NM composition, charge, size on penetration through skin exposed to acute and chronic levels of ultraviolet radiation. Under conditions that NM penetrate skin we will characterize their association with epidermal cells, including antigen presenting cells to establish this as a mechanism of systemic transport. We will determine if and how NM may impact UVB induced immunosuppression and allergic contact hypersensitivity. Finally, we will determine if measuring inside-out water loss from skin is a viable means to assess outside-in NM penetration risk. This project will produce a concise body of work that will aid in assessing risk factors associated with unintentional NM skin exposure and discover novel mechanisms by which NM may impact skin immune function.
The expanding use of engineered nanomaterials (NM) in consumer products and technological applications has spurred environmental and consumer health and safety (H&S) concerns. This project investigates the question of NM contact on ultraviolet radiation exposed skin.
|Zheng, Hong; Mortensen, Luke J; Ravichandran, Supriya et al. (2017) Effect of Nanoparticle Surface Coating on Cell Toxicity and Mitochondria Uptake. J Biomed Nanotechnol 13:155-66|
|Graham, Uschi M; Jacobs, Gary; Yokel, Robert A et al. (2017) From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity. Adv Exp Med Biol 947:71-100|
|Jatana, Samreen; Palmer, Brian C; Phelan, Sarah J et al. (2017) Immunomodulatory Effects of Nanoparticles on Skin Allergy. Sci Rep 7:3979|
|Jatana, Samreen; Palmer, Brian C; Phelan, Sarah J et al. (2017) In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation. Part Fibre Toxicol 14:12|
|Palmer, Brian C; DeLouise, Lisa A (2016) Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting. Molecules 21:|
|Jatana, Samreen; Callahan, Linda M; Pentland, Alice P et al. (2016) Impact of Cosmetic Lotions on Nanoparticle Penetration through ex vivo C57BL/6 Hairless Mouse and Human Skin: A Comparison Study. Cosmetics 3:|
|Mortensen, Luke J; Faulknor, Renea; Ravichandran, Supriya et al. (2015) UVB Dependence of Quantum Dot Reactive Oxygen Species Generation in Common Skin Cell Models. J Biomed Nanotechnol 11:1644-52|
|Jatana, Samreen; DeLouise, Lisa A (2014) Understanding engineered nanomaterial skin interactions and the modulatory effects of ultraviolet radiation skin exposure. Wiley Interdiscip Rev Nanomed Nanobiotechnol 6:61-79|
|Mortensen, Luke J; Ravichandran, Supriya; Delouise, Lisa A (2013) The impact of UVB exposure and differentiation state of primary keratinocytes on their interaction with quantum dots. Nanotoxicology 7:1244-54|
|Mortensen, Luke J; Jatana, Samreen; Gelein, Robert et al. (2013) Quantification of quantum dot murine skin penetration with UVR barrier impairment. Nanotoxicology 7:1386-98|
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