The expanding use of engineered nanomaterials (NM) in consumer products and technological applications has spurred environmental and consumer health and safety (H&S) concerns. This project investigates the question of NM skin exposure. We take a systematic approach to quantify effect on NM composition, charge, size on penetration through skin exposed to acute and chronic levels of ultraviolet radiation. Under conditions that NM penetrate skin we will characterize their association with epidermal cells, including antigen presenting cells to establish this as a mechanism of systemic transport. We will determine if and how NM may impact UVB induced immunosuppression and allergic contact hypersensitivity. Finally, we will determine if measuring inside-out water loss from skin is a viable means to assess outside-in NM penetration risk. This project will produce a concise body of work that will aid in assessing risk factors associated with unintentional NM skin exposure and discover novel mechanisms by which NM may impact skin immune function.

Public Health Relevance

The expanding use of engineered nanomaterials (NM) in consumer products and technological applications has spurred environmental and consumer health and safety (H&S) concerns. This project investigates the question of NM contact on ultraviolet radiation exposed skin.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES021492-02
Application #
8481550
Study Section
Nanotechnology Study Section (NANO)
Program Officer
Nadadur, Srikanth
Project Start
2012-06-05
Project End
2017-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
2
Fiscal Year
2013
Total Cost
$340,673
Indirect Cost
$120,173
Name
University of Rochester
Department
Dermatology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Zheng, Hong; Mortensen, Luke J; Ravichandran, Supriya et al. (2017) Effect of Nanoparticle Surface Coating on Cell Toxicity and Mitochondria Uptake. J Biomed Nanotechnol 13:155-66
Graham, Uschi M; Jacobs, Gary; Yokel, Robert A et al. (2017) From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity. Adv Exp Med Biol 947:71-100
Jatana, Samreen; Palmer, Brian C; Phelan, Sarah J et al. (2017) Immunomodulatory Effects of Nanoparticles on Skin Allergy. Sci Rep 7:3979
Jatana, Samreen; Palmer, Brian C; Phelan, Sarah J et al. (2017) In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation. Part Fibre Toxicol 14:12
Palmer, Brian C; DeLouise, Lisa A (2016) Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting. Molecules 21:
Jatana, Samreen; Callahan, Linda M; Pentland, Alice P et al. (2016) Impact of Cosmetic Lotions on Nanoparticle Penetration through ex vivo C57BL/6 Hairless Mouse and Human Skin: A Comparison Study. Cosmetics 3:
Mortensen, Luke J; Faulknor, Renea; Ravichandran, Supriya et al. (2015) UVB Dependence of Quantum Dot Reactive Oxygen Species Generation in Common Skin Cell Models. J Biomed Nanotechnol 11:1644-52
Jatana, Samreen; DeLouise, Lisa A (2014) Understanding engineered nanomaterial skin interactions and the modulatory effects of ultraviolet radiation skin exposure. Wiley Interdiscip Rev Nanomed Nanobiotechnol 6:61-79
Mortensen, Luke J; Ravichandran, Supriya; Delouise, Lisa A (2013) The impact of UVB exposure and differentiation state of primary keratinocytes on their interaction with quantum dots. Nanotoxicology 7:1244-54
Mortensen, Luke J; Jatana, Samreen; Gelein, Robert et al. (2013) Quantification of quantum dot murine skin penetration with UVR barrier impairment. Nanotoxicology 7:1386-98

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