Abstract

It has been estimated that functional amblyopia affects approximately 2% of the general population. The development of successful treatment procedures for functional amblyopia must be based on a thorough understanding of the mechanisms involved. Therefore, the present proposal is an application of psychophysics and physiological optics which utilizes an animal model of amblyopia and anomalous binocular vision. Rhesus monkeys with amblyopia caused by stimulus deprivation, strabismus, chronic cycloplegia and prims dissociation will be used as subjects in behavioral experiments on contrast sensitivity, increment-threshold sensitivity and binocular interactions using dichoptic stimuli. Visual evoked potential data will also be collected on the behaving, amblyopic monkeys. The data of amblyopic and nonamblyopic eyes will be compared and interperted on the basis of underlying physiological process which may be used to predict the animals' behavior. Treatment strategies will also be devised and tested on some of the amblyopic monkeys.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY001139-17
Application #
3255707
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1978-01-01
Project End
1991-12-31
Budget Start
1991-01-01
Budget End
1991-12-31
Support Year
17
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Houston
Department
Type
Schools of Optometry/Ophthalmol
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77204

  Publications

Patel, Nimesh; McAllister, Faith; Pardon, Laura et al. (2018) The effects of graded intraocular pressure challenge on the optic nerve head. Exp Eye Res 169:79-90
McAllister, Faith; Harwerth, Ronald; Patel, Nimesh (2018) Assessing the True Intraocular Pressure in the Non-human Primate. Optom Vis Sci 95:113-119
Patel, Nimesh B; Hung, Li-Fang; Harwerth, Ronald S (2017) Postnatal maturation of the fovea in Macaca mulatta using optical coherence tomography. Exp Eye Res 164:8-21
Ivers, Kevin M; Sredar, Nripun; Patel, Nimesh B et al. (2015) In Vivo Changes in Lamina Cribrosa Microarchitecture and Optic Nerve Head Structure in Early Experimental Glaucoma. PLoS One 10:e0134223
Patel, Nimesh B; Sullivan-Mee, Michael; Harwerth, Ronald S (2014) The relationship between retinal nerve fiber layer thickness and optic nerve head neuroretinal rim tissue in glaucoma. Invest Ophthalmol Vis Sci 55:6802-16
Patel, Nimesh B; Lim, Mimi; Gajjar, Avni et al. (2014) Age-associated changes in the retinal nerve fiber layer and optic nerve head. Invest Ophthalmol Vis Sci 55:5134-43
Luo, Xunda; Patel, Nimesh B; Rajagopalan, Lakshmi P et al. (2014) Relation between macular retinal ganglion cell/inner plexiform layer thickness and multifocal electroretinogram measures in experimental glaucoma. Invest Ophthalmol Vis Sci 55:4512-24
Hanlon, Samuel D; Smith, C Wayne; Sauter, Marika N et al. (2014) Integrin-dependent neutrophil migration in the injured mouse cornea. Exp Eye Res 120:61-70
Patel, Nimesh B; Garcia, Brenda; Harwerth, Ronald S (2012) Influence of anterior segment power on the scan path and RNFL thickness using SD-OCT. Invest Ophthalmol Vis Sci 53:5788-98
Wheat, Joe L; Rangaswamy, Nalini V; Harwerth, Ronald S (2012) Correlating RNFL thickness by OCT with perimetric sensitivity in glaucoma patients. J Glaucoma 21:95-101

Showing the most recent 10 out of 73 publications