Abstract

In this project the Principal Investigator describes studies on: 1) transmitter release and synaptic vesicle membrane recycling in the photoreceptor endings of the retina using electrophysiological and morphological techniques; 2) the effects of illumination on the structure of photoreceptor outer segments using rapid freezing at 4 degrees K and electron microscopy; 3) labeling functionally active synaptic endings in the mammalian retina with ultrastructural tracers; 4) connectivity of cone cells in the turtle retina.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY001344-11
Application #
3255917
Study Section
(VID)
Project Start
1977-08-01
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Hirasawa, Hajime; Contini, Massimo; Raviola, Elio (2015) Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons. Philos Trans R Soc Lond B Biol Sci 370:
Hirasawa, Hajime; Betensky, Rebecca A; Raviola, Elio (2012) Corelease of dopamine and GABA by a retinal dopaminergic neuron. J Neurosci 32:13281-91
Contini, Massimo; Lin, Bin; Kobayashi, Kazuto et al. (2010) Synaptic input of ON-bipolar cells onto the dopaminergic neurons of the mouse retina. J Comp Neurol 518:2035-50
Hirasawa, Hajime; Puopolo, Michelino; Raviola, Elio (2009) Extrasynaptic release of GABA by retinal dopaminergic neurons. J Neurophysiol 102:146-58
Storch, K-F; Paz, C; Signorovitch, J et al. (2007) Physiological importance of a circadian clock outside the suprachiasmatic nucleus. Cold Spring Harb Symp Quant Biol 72:307-18
Puopolo, Michelino; Raviola, Elio; Bean, Bruce P (2007) Roles of subthreshold calcium current and sodium current in spontaneous firing of mouse midbrain dopamine neurons. J Neurosci 27:645-56
Dorenbos, Ronald; Contini, Massimo; Hirasawa, Hajime et al. (2007) Expression of circadian clock genes in retinal dopaminergic cells. Vis Neurosci 24:573-80
Puopolo, Michelino; Bean, Bruce P; Raviola, Elio (2005) Spontaneous activity of isolated dopaminergic periglomerular cells of the main olfactory bulb. J Neurophysiol 94:3618-27
MacNeil, Margaret A; Heussy, John K; Dacheux, Ramon F et al. (2004) The population of bipolar cells in the rabbit retina. J Comp Neurol 472:73-86
Gustincich, Stefano; Contini, Massimo; Gariboldi, Manuela et al. (2004) Gene discovery in genetically labeled single dopaminergic neurons of the retina. Proc Natl Acad Sci U S A 101:5069-74

Showing the most recent 10 out of 32 publications