Glaucoma is the second leading cause of blindness in the world, but, with proper treatment, blindness can be avoided in 90% of individuals with glaucoma. Proper treatment begins with the detection of glaucoma. Our long-term goal is to improve the detection of early glaucomatous damage, as well as the detection of progression of such damage. In this proposal, we focus in particular on the macular region, the most important retinal region for everyday visual performance. To better understand glaucomatous damage to the macula, as part of Aim 1, we test the hypothesis that early macular visual defects have a particular, arcuate, form when tested with behavioral tests [i.e. standard automated perimetry (SAP)]. We propose an anatomical framework to understand the basis of these macular arcuate defects. Based upon this framework, specific structural (anatomical) hypotheses are generated to understand the type of patients who may be susceptible to these defects. These hypotheses are tested using SAP, multifocal visual evoked potentials, and a relatively new noninvasive technique for in vivo measurement of the anatomy of the human retina and optic nerve, called frequency domain optical coherence tomography (fdOCT). Glaucoma damages retinal ganglion cells (RGC) and their axons. Most of the in vivo anatomical studies in humans have focused on the retinal nerve fiber layer (RNFL), which is made up of axon of the RGCs. As part of Aim 2, we focus on measuring RGC thickness directly using fdOCT technology. In particular, we test a simple linear model, which relates local SAP field loss to RGC loss. In addition, we test the hypothesis that RGC loss is a more sensitive measure than peripapillary RNFL thickness for detecting macular damage Finally, in Aim 3 we use our linear structure-function model to improve our ability to detect glaucomatous damage and its progression. In particular, we use the model to predict the progression of structural and functional damage in patients with glaucoma and to predict the relative effectiveness of different tests for detecting glaucoma. Further, our theoretical framework allows us to test hypotheses about why different tests of glaucoma may or may not agree.

Public Health Relevance

Glaucoma is the second leading cause of blindness in the world, but, with early detection and proper treatment, blindness can be avoided in 90% of individuals with glaucoma. We seek to improve our ability to detect and understand early damage to the most important region of the eye for everyday functions, the macula.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002115-36
Application #
8403023
Study Section
Anterior Eye Disease Study Section (AED)
Program Officer
Chin, Hemin R
Project Start
1977-08-01
Project End
2015-12-31
Budget Start
2013-01-01
Budget End
2013-12-31
Support Year
36
Fiscal Year
2013
Total Cost
$374,697
Indirect Cost
$122,048
Name
Columbia University (N.Y.)
Department
Psychology
Type
Other Domestic Higher Education
DUNS #
049179401
City
New York
State
NY
Country
United States
Zip Code
10027
Grillo, Lola M; Nguyen, Huy V; Tsang, Stephen H et al. (2016) Cobalt-Chromium Metallosis With Normal Electroretinogram. J Neuroophthalmol 36:383-388
Grillo, Lola M; Wang, Diane L; Ramachandran, Rithambara et al. (2016) The 24-2 Visual Field Test Misses Central Macular Damage Confirmed by the 10-2 Visual Field Test and Optical Coherence Tomography. Transl Vis Sci Technol 5:15
Hood, Donald C; De Cuir, Nicole; Blumberg, Dana M et al. (2016) A Single Wide-Field OCT Protocol Can Provide Compelling Information for the Diagnosis of Early Glaucoma. Transl Vis Sci Technol 5:4
Hood, Donald C; De Cuir, Nicole; Mavrommatis, Maria A et al. (2016) Defects Along Blood Vessels in Glaucoma Suspects and Patients. Invest Ophthalmol Vis Sci 57:1680-6
Chen, Monica F; Chui, Toco Y P; Alhadeff, Paula et al. (2015) Adaptive optics imaging of healthy and abnormal regions of retinal nerve fiber bundles of patients with glaucoma. Invest Ophthalmol Vis Sci 56:674-81
Hood, Donald C; Chen, Monica F; Lee, Dongwon et al. (2015) Confocal Adaptive Optics Imaging of Peripapillary Nerve Fiber Bundles: Implications for Glaucomatous Damage Seen on Circumpapillary OCT Scans. Transl Vis Sci Technol 4:12
Hood, Donald C; Xin, Daiyan; Wang, Diane et al. (2015) A Region-of-Interest Approach for Detecting Progression of Glaucomatous Damage With Optical Coherence Tomography. JAMA Ophthalmol 133:1438-44
Raza, Ali S; Hood, Donald C (2015) Evaluation of a Method for Estimating Retinal Ganglion Cell Counts Using Visual Fields and Optical Coherence Tomography. Invest Ophthalmol Vis Sci 56:2254-68
Wang, Diane L; Raza, Ali S; de Moraes, Carlos Gustavo et al. (2015) Central Glaucomatous Damage of the Macula Can Be Overlooked by Conventional OCT Retinal Nerve Fiber Layer Thickness Analyses. Transl Vis Sci Technol 4:4
Raza, Ali S; Hood, Donald C (2015) Evaluation of the Structure-Function Relationship in Glaucoma Using a Novel Method for Estimating the Number of Retinal Ganglion Cells in the Human Retina. Invest Ophthalmol Vis Sci 56:5548-56

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