The proposed studies seek to understand how cortical and midbrain centers interact in mediating visually guided behaviors and how this interaction may be important for our ability to restore visual capacities in the cortically blind animal. The ability of an animal to detect and orient towards a novel stimulus (the """"""""orienting response') is permanently lost in the blind hemifield opposite to a large cortical lesion. Destruction of the crossed subcortical pathway from the substantia nigra """"""""critical zone"""""""" to the superior colliculus results in a rapid recovery of the orienting response in the previously blind hemifield. We propose: 1) to study the origin of the pathways that produce the recovery as they course through the commissure of the superior colliculus; 2) to study the input and output connections of that zone of the substantia nigra responsible for the recovery; 3) to test the hypothesis that the ipsilateral substantia nigra also may play a role in visual recovery; 4) to learn if pharmacological agents applied to the substantia nigra or superior colliculus will produce either a recovery or loss of visual orienting, and 5) to learn why neurotoxin lesions of one superior colliculus produce an enduring loss of vision that appears indistinguishable from cortical blindness. It is now clear that the visual cortex is neither necessary nor sufficient for visual orientation behavior in the cat. It is also clear in all species thus far studied that the substantia nigra, pars reticulata exerts a powerful inhibitory effect on cells in the deeper layers of the superior colliculus which function to mediate visuomotor behaviors such as the orienting response. Our ability to produce or eliminate a hemifield blindness or neglect by activation or inactivation of this and related subcortical circuits point to their importance in normal vision and may lead to therapeutic interventions in humans suffering from syndromes of sensory loss or neglect, e.g. cortical blindness. Finally, this work adds to our recent appreciation that the nigrotectal connection is a major output pathway by which the basal ganglia control sensorimotor functions.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002654-15
Application #
3256980
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1978-09-01
Project End
1996-11-30
Budget Start
1992-12-01
Budget End
1993-11-30
Support Year
15
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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