Abstract

The proposed research seeks to determine variables important in the loss or preservation of ganglion cells of the retina after cortical lesions as a consequence of transneuronal retrograde degeneration in primates and other mammals. After longstanding cortical lesions produce such ganglion cell loss, the projection patterns of the remaining ganglion cells will be studied by autoradiographic procedures. These studies will document the conditions of ganglion cell loss, lead to a better understanding of the phenomenon of transneuronal retrograde degeneration, and provide basic information on the central connections of different cell classes of the retina.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002686-11
Application #
3257025
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1978-06-01
Project End
1986-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
Schools of Arts and Sciences
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37203

  Publications

Saraf, Mansi P; Balaram, Pooja; Pifferi, Fabien et al. (2018) Architectonic features and relative locations of primary sensory and related areas of neocortex in mouse lemurs. J Comp Neurol :
Takahata, Toru; Patel, Nimesh B; Balaram, Pooja et al. (2018) Long-term histological changes in the macaque primary visual cortex and the lateral geniculate nucleus after monocular deprivation produced by early restricted retinal lesions and diffuser induced form deprivation. J Comp Neurol 526:2955-2972
Krueger, Juliane; Disney, Anita A (2018) Structure and function of dual-source cholinergic modulation in early vision. J Comp Neurol :
Baldwin, Mary K L; Balaram, Pooja; Kaas, Jon H (2017) The evolution and functions of nuclei of the visual pulvinar in primates. J Comp Neurol 525:3207-3226
Takahata, Toru; Kaas, Jon H (2017) c-FOS expression in the visual system of tree shrews after monocular inactivation. J Comp Neurol 525:151-165
Stepniewska, Iwona; Cerkevich, Christina M; Kaas, Jon H (2016) Cortical Connections of the Caudal Portion of Posterior Parietal Cortex in Prosimian Galagos. Cereb Cortex 26:2753-77
Kaas, Jon H; Stepniewska, Iwona (2016) Evolution of posterior parietal cortex and parietal-frontal networks for specific actions in primates. J Comp Neurol 524:595-608
Gharbawie, Omar A; Stepniewska, Iwona; Kaas, Jon H (2016) The origins of thalamic inputs to grasp zones in frontal cortex of macaque monkeys. Brain Struct Funct 221:3123-40
Cooke, Dylan F; Stepniewska, Iwona; Miller, Daniel J et al. (2015) Reversible Deactivation of Motor Cortex Reveals Functional Connectivity with Posterior Parietal Cortex in the Prosimian Galago (Otolemur garnettii). J Neurosci 35:14406-22
Balaram, P; Isaamullah, M; Petry, H M et al. (2015) Distributions of vesicular glutamate transporters 1 and 2 in the visual system of tree shrews (Tupaia belangeri). J Comp Neurol 523:1792-808

Showing the most recent 10 out of 129 publications