The goal of this proposal is to determine how posterior parietal cortex (PPC) of primates is organized and functions in sensorimotor behavior. Posterior parietal cortex is currently thought to play a critical role in the planning and the initiation of various sensory guided behaviors such as reaching, grasping, and looking, while providing outputs to premotor and motor cortex that organize the motor behaviors. Over the last grant period we have greatly extended this important framework by providing clear evidence that approximately 7-8 different subregions or domains of PPC initiate different classes of movements when electrically stimulated in monkeys and other primates (grasping, reaching, looking, head defense, body defense, aggressive expression, climbing). Moreover, we defined functionally matching domains in premotor cortex and primary motor cortex where matching classes of complex movements are evoked by electrical stimulation. We have identified anatomical connections between matching domains, and visual and somatosensory inputs to PPC domains. We now plan experiments to reveal the functional relationship between matched PPC and motor domains, how domains of different types interact, and how domains differ in the proportions and types of visual and somatosensory inputs they receive to guide motor behaviors. We also expect to determine if matching or electrically evoked behaviors recover after we lesion specific domains, and if so, how the brain reorganizes to mediate behavioral recoveries. Our methods of investigation include electrical microstimulation of domains, the chemical inactivation or potentiation of domains, the reversible inactivation of domains with a cooling probe, behavioral studies after lesions of domains, the recordings of neural activity with arrays of microelectrodes, and the use of anatomical and histological methods to reveal brain connections and structural subdivisions of the cortex. The results are expected to produce a new and greatly expanded understandings of the functional organization of PPC in primates, how functional domains in PPC interact with each other, how they are guided by sensory information, and how they mediate different classes of behaviors by activating matching parts of frontal motor fields. The results will lead to a better understanding of the impairments that resul in humans after PPC damage, and indicate the levels and time courses of recovery. The results will also suggest modes of clinical treatment that are open to experimental validation.

Public Health Relevance

The goal of our project is to determine how subregions of posterior parietal cortex mediate classes of useful behaviors, such as reaching and grasping food. These studies will reveal neural networks for such behaviors and provide an understanding that will have clinical relevance for treatments and recoveries after stroke or other damage to posterior parietal cortex.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY002686-37A1
Application #
8760556
Study Section
(SPC)
Program Officer
Araj, Houmam H
Project Start
1978-06-01
Project End
2019-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
37
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Kaas, Jon H; Stepniewska, Iwona (2016) Evolution of posterior parietal cortex and parietal-frontal networks for specific actions in primates. J Comp Neurol 524:595-608
Balaram, P; Isaamullah, M; Petry, H M et al. (2015) Distributions of vesicular glutamate transporters 1 and 2 in the visual system of tree shrews (Tupaia belangeri). J Comp Neurol 523:1792-808
Cooke, Dylan F; Stepniewska, Iwona; Miller, Daniel J et al. (2015) Reversible Deactivation of Motor Cortex Reveals Functional Connectivity with Posterior Parietal Cortex in the Prosimian Galago (Otolemur garnettii). J Neurosci 35:14406-22
Stepniewska, Iwona; Gharbawie, Omar A; Burish, Mark J et al. (2014) Effects of muscimol inactivations of functional domains in motor, premotor, and posterior parietal cortex on complex movements evoked by electrical stimulation. J Neurophysiol 111:1100-19
Balaram, Pooja; Young, Nicole A; Kaas, Jon H (2014) Histological features of layers and sublayers in cortical visual areas V1 and V2 of chimpanzees, macaque monkeys, and humans. Eye Brain 2014:5-18
Cerkevich, Christina M; Lyon, David C; Balaram, Pooja et al. (2014) Distribution of cortical neurons projecting to the superior colliculus in macaque monkeys. Eye Brain 2014:121-137
Kaas, Jon H; Balaram, Pooja (2014) Current research on the organization and function of the visual system in primates. Eye Brain 6:1-4
Cerkevich, Christina M; Collins, Christine E; Kaas, Jon H (2014) Cortical inputs to the middle temporal visual area in New World owl monkeys. Eye Brain 2015:1-15
Takahata, Toru; Miyashita, Masanobu; Tanaka, Shigeru et al. (2014) Identification of ocular dominance domains in New World owl monkeys by immediate-early gene expression. Proc Natl Acad Sci U S A 111:4297-302
Rockoff, Emily C; Balaram, Pooja; Kaas, Jon H (2014) Patchy distributions of myelin and vesicular glutamate transporter 2 align with cytochrome oxidase blobs and interblobs in the superficial layers of the primary visual cortex. Eye Brain 6:19-27

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