Abstract

This study is designed to reexamine a well characterized cohort of 2,366 diabetic persons in Southern Wisconsin in order to determine progression and new development of diabetic retinopathy and visual impairment. Participants will be examined in their home communities in a mobile examining van. As part of the evaluation, refraction, visual acuity, intraocular and blood pressure measurments according to standardized protocols, and determination of urine protein, blood glycosylated hemoglobin, and plasma C-peptide levels will be performed. Objective recording of retinopathy by use of stereoscopic fundus photography combined with a standardized protocol for grading the retinopathy will be used. Grading of the stereo photographs will provide a sensitive and reproducible method for detection of the appearance or progression of retinopathy. The incidence and causes of visual impairment will be determined. The incidence of retinopathy and of its various component lesions will be evaluated with respect to risk factors, such as duration and age at diagnosis of diabetes, glycosylated hemoglobin level, blood pressure level and smoking history as ascertained four years previously. The vital status of patients will be determined to provide data regarding the relationship between severity of retinopathy and other characteristics with prognosis for life.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003083-07
Application #
3257369
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1979-07-01
Project End
1989-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Roshandel, Delnaz; Gubitosi-Klug, Rose; Bull, Shelley B et al. (2018) Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes. Diabetologia 61:1098-1111
Verhoeven, Virginie J M; Hysi, Pirro G; Wojciechowski, Robert et al. (2013) Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet 45:314-8
Grassi, Michael A; Tikhomirov, Anna; Ramalingam, Sudha et al. (2012) Replication analysis for severe diabetic retinopathy. Invest Ophthalmol Vis Sci 53:2377-81
Klein, Barbara E K; Lee, Kristine E; Klein, Ronald (2011) Refraction in adults with diabetes. Arch Ophthalmol 129:56-62
Klein, Ronald; Klein, Barbara E K (2010) Are individuals with diabetes seeing better?: a long-term epidemiological perspective. Diabetes 59:1853-60
Cooper, Rachel; Kuh, Diana; Hardy, Rebecca et al. (2010) Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ 341:c4467
Klein, Ronald; Lee, Kristine E; Gangnon, Ronald E et al. (2010) The 25-year incidence of visual impairment in type 1 diabetes mellitus the wisconsin epidemiologic study of diabetic retinopathy. Ophthalmology 117:63-70
Grassi, Michael A; Mazzulla, D Anthony; Knudtson, Michael D et al. (2009) Patient self-report of prior laser treatment reliably indicates presence of severe diabetic retinopathy. Am J Ophthalmol 147:501-4
Klein, Barbara E K; Knudtson, Michael D; Tsai, Michael Y et al. (2009) The relation of markers of inflammation and endothelial dysfunction to the prevalence and progression of diabetic retinopathy: Wisconsin epidemiologic study of diabetic retinopathy. Arch Ophthalmol 127:1175-82
Klein, Ronald; Knudtson, Michael D; Lee, Kristine E et al. (2009) The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetes. Ophthalmology 116:497-503

Showing the most recent 10 out of 163 publications