A new technique, called Hartmann wavefront sensing, will be used to measure the aberrations of the human eye. With a single flash, this automated technique can provide a complete description of the eye's aberrations, including irregular aberrations that have not been characterized before. The effect of irregular aberrations on the quality of the retinal image can be determined for the first time. The wavefront sensing technique may improve autorefraction, contact lens design, and the evaluation of outcomes following ocular surgery. A new, high- resolution fundus camera will be constructed that is equipped with adaptive optics. The camera will automatically measure the wave aberration with a Hartmann wavefront sensor and then correct it with a deformable mirror.When acquiring fundus images through a 6 mm pupil, this camera should provide a 3-fold increase in transverse resolution and a 9-fold increase in axial resolution over conventional fundus imaging. The instrument should be capable of resolving retinal structures as small as foveal cones or the larger fibers in the nerve fiber layer in the living human eye. The nature of the light reflection from single cones in the living human fundus will be determined. Ultimately, the device may be useful in characterizing photoreceptor pathology in vivo. Adaptive optics can also provide an observer with better retinal image quality than he/she has experienced. We will measure visual performance when observers view natural stimuli through a deformable mirror that corrects the wave aberration of the eye. These measurements will clarify the relationship between optical and neural factors in spatial vision.
Song, Hongxin; Rossi, Ethan A; Stone, Edwin et al. (2018) Phenotypic diversity in autosomal-dominant cone-rod dystrophy elucidated by adaptive optics retinal imaging. Br J Ophthalmol 102:136-141 |
Schwarz, Christina; Sharma, Robin; Cheong, Soon Keen et al. (2018) Selective S Cone Damage and Retinal Remodeling Following Intense Ultrashort Pulse Laser Exposures in the Near-Infrared. Invest Ophthalmol Vis Sci 59:5973-5984 |
Granger, Charles E; Yang, Qiang; Song, Hongxin et al. (2018) Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic. Invest Ophthalmol Vis Sci 59:5705-5716 |
de la Barca, Juan Manuel Chao; Huang, Nuan-Ting; Jiao, Haihan et al. (2017) Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics. Metabolomics 13:22 |
Marcos, Susana; Werner, John S; Burns, Stephen A et al. (2017) Vision science and adaptive optics, the state of the field. Vision Res 132:3-33 |
Rossi, Ethan A; Granger, Charles E; Sharma, Robin et al. (2017) Imaging individual neurons in the retinal ganglion cell layer of the living eye. Proc Natl Acad Sci U S A 114:586-591 |
Schwarz, Christina; Sharma, Robin; Fischer, William S et al. (2016) Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express 7:5148-5169 |
Liu, Zhao; Ueda, Keiko; Kim, Hye Jin et al. (2015) Photobleaching and Fluorescence Recovery of RPE Bisretinoids. PLoS One 10:e0138081 |
Masella, Benjamin D; Hunter, Jennifer J; Williams, David R (2014) New wrinkles in retinal densitometry. Invest Ophthalmol Vis Sci 55:7525-34 |
Strazzeri, Jennifer M; Hunter, Jennifer J; Masella, Benjamin D et al. (2014) Focal damage to macaque photoreceptors produces persistent visual loss. Exp Eye Res 119:88-96 |
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