A highly collaborative team at the University of Rochester led by Jennifer Hunter and David Williams will translate in vivo two-photon excited fluorescence ophthalmoscopy (TPEFO) from monkey to human. This technology has the potential to provide new information on microscopic retinal morphology and to serve as a superior, objective measure to assess retinal function, a rare capability among existing imaging technologies. Effects of IR autofluorescence reduction, currently the only noticeable, consequence of TPEFO will be characterized. Additionally, we will establish thresholds for retinal damage. Monitoring retinal health in cortically blind human subjects after repeated TPEF imaging will establish whether TPEFO can be applied safely to normal human eyes.
Investigators at the University of Rochester will develop a new way to take high resolution pictures of the inside of the living human eye using the fluorescence properties of molecules that play key roles in normal retinal function. Once we have established that this method can be used safely in human eyes, it may reveal the health of the light-sensitive rod and cones that are damaged by diseases of the retina such as retinal degeneration.
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| Schwarz, Christina; Sharma, Robin; Cheong, Soon Keen et al. (2018) Selective S Cone Damage and Retinal Remodeling Following Intense Ultrashort Pulse Laser Exposures in the Near-Infrared. Invest Ophthalmol Vis Sci 59:5973-5984 |
| Granger, Charles E; Yang, Qiang; Song, Hongxin et al. (2018) Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic. Invest Ophthalmol Vis Sci 59:5705-5716 |
| de la Barca, Juan Manuel Chao; Huang, Nuan-Ting; Jiao, Haihan et al. (2017) Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics. Metabolomics 13:22 |
| Marcos, Susana; Werner, John S; Burns, Stephen A et al. (2017) Vision science and adaptive optics, the state of the field. Vision Res 132:3-33 |
| Rossi, Ethan A; Granger, Charles E; Sharma, Robin et al. (2017) Imaging individual neurons in the retinal ganglion cell layer of the living eye. Proc Natl Acad Sci U S A 114:586-591 |
| Schwarz, Christina; Sharma, Robin; Fischer, William S et al. (2016) Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express 7:5148-5169 |
| Liu, Zhao; Ueda, Keiko; Kim, Hye Jin et al. (2015) Photobleaching and Fluorescence Recovery of RPE Bisretinoids. PLoS One 10:e0138081 |
| Masella, Benjamin D; Hunter, Jennifer J; Williams, David R (2014) New wrinkles in retinal densitometry. Invest Ophthalmol Vis Sci 55:7525-34 |
| Strazzeri, Jennifer M; Hunter, Jennifer J; Masella, Benjamin D et al. (2014) Focal damage to macaque photoreceptors produces persistent visual loss. Exp Eye Res 119:88-96 |
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