Abstract

Dr. Wu proposes to study synaptic inputs to bipolar cells in the retina. The studies will concentrate on the analysis of distinctions between rod and cone inputs to ON and OFF bipolar cells; structure-function comparisons of four general classes of bipolar cells, analysis of lateral inputs from horizontal and amacrine cells, and a description of the excitatory and inhibitory amino acid pharmacology of these synapses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY004446-17
Application #
2710850
Study Section
Special Emphasis Panel (ZRG1-VISB (02))
Project Start
1982-02-01
Project End
2000-09-29
Budget Start
1998-09-30
Budget End
1999-09-29
Support Year
17
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Pang, Ji-Jie; Yang, Zhuo; Jacoby, Roy A et al. (2018) Cone synapses in mammalian retinal rod bipolar cells. J Comp Neurol 526:1896-1909
Cowan, Cameron S; Sabharwal, Jasdeep; Seilheimer, Robert L et al. (2017) Distinct subcomponents of mouse retinal ganglion cell receptive fields are differentially altered by light adaptation. Vision Res 131:96-105
Tse, Dennis Y; Kim, Seong Jae; Chung, Inyoung et al. (2017) The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice. Int J Ophthalmol 10:1361-1369
He, Feng; Agosto, Melina A; Anastassov, Ivan A et al. (2016) Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods. Sci Rep 6:26978
Wang, Jing; Jacoby, Roy; Wu, Samuel M (2016) Physiological and morphological characterization of ganglion cells in the salamander retina. Vision Res 119:60-72
Cowan, Cameron S; Abd-El-Barr, Muhammad; van der Heijden, Meike et al. (2016) Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes. Vision Res 119:99-109
Eblimit, Aiden; Nguyen, Thanh-Minh T; Chen, Yiyun et al. (2015) Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina. Hum Mol Genet 24:1584-601
Khan, A Kareem; Tse, Dennis Y; van der Heijden, Meike E et al. (2015) Prolonged elevation of intraocular pressure results in retinal ganglion cell loss and abnormal retinal function in mice. Exp Eye Res 130:29-37
Kim, Jin Young; Song, Ji Yun; Karnam, Santi et al. (2015) Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye. Gene Expr Patterns 17:31-7
Xiong, Wei-Hong; Pang, Ji-Jie; Pennesi, Mark E et al. (2015) The Effect of PKC? on the Light Response of Rod Bipolar Cells in the Mouse Retina. Invest Ophthalmol Vis Sci 56:4961-74

Showing the most recent 10 out of 123 publications