Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY006044-19
Application #
6628636
Study Section
Visual Sciences A Study Section (VISA)
Program Officer
Liberman, Ellen S
Project Start
1985-01-01
Project End
2006-01-31
Budget Start
2003-02-01
Budget End
2006-01-31
Support Year
19
Fiscal Year
2003
Total Cost
$331,300
Indirect Cost
Name
University of California Los Angeles
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Jing, Zhe; Gangalum, Rajendra K; Bhat, Ankur M et al. (2014) HSF4 mutation p.Arg116His found in age-related cataracts and in normal populations produces childhood lamellar cataract in transgenic mice. Hum Mutat 35:1068-71
Jing, Zhe; Gangalum, Rajendra K; Mock, Dennis C et al. (2014) A gene-specific non-enhancer sequence is critical for expression from the promoter of the small heat shock protein gene ?B-crystallin. Hum Genomics 8:5
Gangalum, Rajendra K; Jing, Zhe; Bhat, Ankur M et al. (2014) Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice. Invest Ophthalmol Vis Sci 55:7227-40
Gangalum, Rajendra K; Horwitz, Joseph; Kohan, Sirus A et al. (2012) ?A-crystallin and ?B-crystallin reside in separate subcellular compartments in the developing ocular lens. J Biol Chem 287:42407-16
Rao, Narsing A; Saraswathy, Sindhu; Pararajasegaram, Geeta et al. (2012) Small heat shock protein ýýA-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis. PLoS One 7:e33582
Gangalum, Rajendra K; Bhat, Suraj P (2009) AlphaB-crystallin: a Golgi-associated membrane protein in the developing ocular lens. Invest Ophthalmol Vis Sci 50:3283-90
Nagineni, C N; Bhat, S P (1992) Lens fiber cell differentiation and expression of crystallins in co-cultures of human fetal lens epithelial cells and fibroblasts. Exp Eye Res 54:193-200
Porrello, K; Bhat, S P; Bok, D (1991) Detection of interphotoreceptor retinoid binding protein (IRBP) mRNA in human and cone-dominant squirrel retinas by in situ hybridization. J Histochem Cytochem 39:171-6
Bhat, S P (1990) Synthesis of nucleic acid probes on membrane supports: a procedure for the removal of unincorporated precursors. Anal Biochem 184:59-62
Nagineni, C N; Bhat, S P (1989) Alpha B-crystallin is expressed in kidney epithelial cell lines and not in fibroblasts. FEBS Lett 249:89-94

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