Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY006400-07A3
Application #
2160133
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1993-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Physiology
Type
Schools of Optometry/Ophthalmol
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Srivastava, O P; Srivastava, K; Chaves, J M et al. (2017) Post-translationally modified human lens crystallin fragments show aggregation in vitro. Biochem Biophys Rep 10:94-131
Chaves, Jose M; Gupta, Ratna; Srivastava, Kiran et al. (2017) Human alpha A-crystallin missing N-terminal domain poorly complexes with filensin and phakinin. Biochem Biophys Res Commun 494:402-408
Hegde, Shylaja; Kesterson, Robert A; Srivastava, Om P (2016) CRY?A3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation. PLoS One 11:e0149027
Tiwary, Ekta; Hegde, Shylaja; Purushotham, Sangeetha et al. (2015) Interaction of ?A3-Crystallin with Deamidated Mutants of ?A- and ?B-Crystallins. PLoS One 10:e0144621
Hegde, Shylaja M; Srivastava, Kiran; Tiwary, Ekta et al. (2014) Molecular mechanism of formation of cortical opacity in CRYAAN101D transgenic mice. Invest Ophthalmol Vis Sci 55:6398-408
Gupta, Ratna; Asomugha, Chinwe O; Srivastava, Om P (2011) The common modification in alphaA-crystallin in the lens, N101D, is associated with increased opacity in a mouse model. J Biol Chem 286:11579-92
Asomugha, C O; Gupta, R; Srivastava, O P (2010) Identification of crystallin modifications in the human lens cortex and nucleus using laser capture microdissection and CyDye labeling. Mol Vis 16:476-94
Gupta, R; Chen, J; Srivastava, O P (2010) A serine-type protease activity of human lens ?A3-crystallin is responsible for its autodegradation. Mol Vis 16:2242-52
Gupta, Ratna; Srivastava, Om P (2009) Identification of interaction sites between human betaA3- and alphaA/alphaB-crystallins by mammalian two-hybrid and fluorescence resonance energy transfer acceptor photobleaching methods. J Biol Chem 284:18481-92
Srivastava, K; Gupta, R; Chaves, J M et al. (2009) Truncated human betaB1-crystallin shows altered structural properties and interaction with human betaA3-crystallin. Biochemistry 48:7179-89