This proposal is focused on aspects of visual adaptation in the vertebrate retina. The proposal is divided into three broad aims: (1) to clone, sequence and express connexins from skate and catfish retina and perform functional and comparative studies; (2) to identify, with electrophysiological methods, the GABA receptors of bipolar cells and Muller cells in the skate retina and to examine their modulation; and (3) to assess the role of IRBP in retinal development and the rhodopsin cycle. In the latter aim, a variety of studies will be conducted on transgenic mice with an IRBP knockout or partial expression.
| Qian, Haohua; Shah, Manthan R; Alexander, Kenneth R et al. (2008) Two distinct processes are evident in rat cone flicker ERG responses at low and high temporal frequencies. Exp Eye Res 87:71-5 |
| Chappell, Richard L; Anastassov, Ivan; Lugo, Prospero et al. (2008) Zinc-mediated feedback at the synaptic terminals of vertebrate photoreceptors. Exp Eye Res 87:394-7 |
| Ramsey, David J; Ripps, Harris; Qian, Haohua (2007) Streptozotocin-induced diabetes modulates GABA receptor activity of rat retinal neurons. Exp Eye Res 85:413-22 |
| Zhu, Yujie; Ripps, Harris; Qian, Haohua (2007) A single amino acid in the second transmembrane domain of GABA rho receptors regulates channel conductance. Neurosci Lett 418:205-9 |
