Associative recall of sensory experiences is part-and-parcel of perception. Through a ubiquitous and automatic process, incomplete, noisy and ambiguous signals ascending from the sensory periphery are fleshed-out and disambiguated by associative memories. Consistent with this view, functional brain imaging studies in humans have shown that recall of visual pictorial memories is correlated with top-down activation of the same cortical areas that process incoming visual stimuli. Using a combination of neurophysiological and behavioral approaches, we have recently begun to explore top-down associative recall signals at the cellular level in primate visual cortex, and to relate these cellular signals to visual imagery and perception. Most importantly, we have discovered highly specific associative recall signals in cortical visual area MT, an area that plays a central role in visual motion processing. Our findings suggest a novel model system for detailed quantitative investigation of the functions and neuronal mechanisms of pictorial memory recall. We have proposed a series of neurophysiological and behavioral experiments designed to improve understanding of the source and plasticity of top-down recall signals, their distribution throughout visual cortex, and the interactions between recall and bottom-up visual sensations. By these means we hope to reveal the dynamic interplay between memory, imagery and perception. The long-term goal of this project is to contribute to the understanding of biological substrates of perception and cognition. Detailed knowledge of the normal functions of visual cortex shall provide insights into the neural events that underlie visual memory, imagery, dreaming and manifestations of perceptual disorders, such as hallucinations. Such information will ultimately aid in the treatment and prevention of neurological and neuropsychiatric disorders of visual perception and memory.
These aims are pertinent to the development and use of prosthetic, behavioral, and pharmacological therapies for the visually and mnemonically handicapped.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007605-22
Application #
8120714
Study Section
Cognitive Neuroscience Study Section (COG)
Program Officer
Steinmetz, Michael A
Project Start
1988-04-01
Project End
2012-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
22
Fiscal Year
2011
Total Cost
$455,004
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
078731668
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Albright, Thomas D (2012) On the perception of probable things: neural substrates of associative memory, imagery, and perception. Neuron 74:227-45
Lesmes, Luis Andres; Lu, Zhong-Lin; Baek, Jongsoo et al. (2010) Bayesian adaptive estimation of the contrast sensitivity function: the quick CSF method. J Vis 10:17.1-21
Buracas, Giedrius T; Albright, Thomas D (2009) Modulation of neuronal responses during covert search for visual feature conjunctions. Proc Natl Acad Sci U S A 106:16853-8
Huang, Xin; Albright, Thomas D; Stoner, Gene R (2008) Stimulus dependency and mechanisms of surround modulation in cortical area MT. J Neurosci 28:13889-906
Schlack, Anja; Krekelberg, Bart; Albright, Thomas D (2008) Speed perception during acceleration and deceleration. J Vis 8:9.1-11
Duncan, R O; Albright, T D; Stoner, G R (2000) Occlusion and the interpretation of visual motion: perceptual and neuronal effects of context. J Neurosci 20:5885-97
Croner, L J; Albright, T D (1999) Segmentation by color influences responses of motion-sensitive neurons in the cortical middle temporal visual area. J Neurosci 19:3935-51
Dobkins, K R; Stoner, G R; Albright, T D (1998) Perceptual, oculomotor, and neural responses to moving color plaids. Perception 27:681-709
Croner, L J; Albright, T D (1997) Image segmentation enhances discrimination of motion in visual noise. Vision Res 37:1415-27
Chaudhuri, A; Albright, T D (1997) Neuronal responses to edges defined by luminance vs. temporal texture in macaque area V1. Vis Neurosci 14:949-62

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