(from abstract): The long-term objective of this research is to relate functional deficits in patients with visual disorders to underlying cellular pathophysiology. A better understanding of these relationships will be useful in design of treatment trials, in selecting tests for evaluation of individual patients, and in guiding biomolecular and physiological studies. The research uses quantitative models, rigorous psychophysical methods, and carefully selected patient populations to investigate the linkage between functional defects and biological damage. The proposed research focuses on psychophysical measures of ganglion cell function in relative scotomas (local regions of reduced sensitivity) in patients with progressive diseases which primarily damage only one class of neuron: retinal ganglion cells (glaucoma) or photoreceptors (retinitis pigmentosa). For both diseases, there is debate over the effects of cell damage, and over the mechanisms of cell death. There are 3 specific aims: 1 ) To model effects of ganglion cell damage on perimetric thresholds. and to apply these models to patient data. Qualitative models have been proposed to account for relative scotomas in terms of retinal ganglion cell damage, but quantitative models have not been developed. Data on human and macaque ganglion cell mosaics will be used to build a quantitative model to link ganglion cell damage with perimetric threshold elevations, and apply this to normal and patient data gathered with both standard perimetric stimuli and innovative stimuli. 2) To investigate reversibility of visual deficits caused by glaucoma. It is debated whether glaucomatous defects are reversible. Local sensitivity of discrete ganglion cell mosaics will be measured in patients with glaucoma before and after acute surgical reduction of intraocular pressure to determine if visual function improves. 3) To evaluate temporal processing in relative scotomas of patients with retinitis pigmentosa (RP). There is debate over whether temporal defects in RP are due to reduction in cone sensitivity (reduced quantal catch and/or transduction efficiency), or to a temporal processing defect in the cones or the inner retina. Temporal sensitivity will be measured in relative scotomas of patients with RP, at a mean retinal illuminance which allows cone sensitivity loss to be distinguished from purely temporal.
| Alluwimi, Muhammed S; Swanson, William H; King, Brett J (2018) Identifying Glaucomatous Damage to the Macula. Optom Vis Sci 95:96-105 |
| Ramezani, Koosha; Marín-Franch, Iván; Hu, Rongrong et al. (2018) Prediction Accuracy of the Dynamic Structure-Function Model for Glaucoma Progression Using Contrast Sensitivity Perimetry and Confocal Scanning Laser Ophthalmoscopy. J Glaucoma 27:785-793 |
| Swanson, William H; Dul, Mitchell W; Horner, Douglas G et al. (2017) Individual differences in the shape of the nasal visual field. Vision Res 141:23-29 |
| Price, Derek A; Swanson, William H; Horner, Douglas G (2017) Using perimetric data to estimate ganglion cell loss for detecting progression of glaucoma: a comparison of models. Ophthalmic Physiol Opt 37:409-419 |
| Gardiner, Stuart K; Swanson, William H; Demirel, Shaban (2016) The Effect of Limiting the Range of Perimetric Sensitivities on Pointwise Assessment of Visual Field Progression in Glaucoma. Invest Ophthalmol Vis Sci 57:288-94 |
| Ashimatey, Bright S; Swanson, William H (2016) Between-Subject Variability in Healthy Eyes as a Primary Source of Structural-Functional Discordance in Patients With Glaucoma. Invest Ophthalmol Vis Sci 57:502-7 |
| Swanson, William H; Dul, Mitchell W; Horner, Douglas G et al. (2016) Contrast sensitivity perimetry data from adults free of eye disease. Data Brief 8:654-8 |
| Dul, Mitchell; Ennis, Robert; Radner, Shira et al. (2015) Retinal adaptation abnormalities in primary open-angle glaucoma. Invest Ophthalmol Vis Sci 56:1329-34 |
| Swanson, William H; Horner, Douglas G (2015) Assessing assumptions of a combined structure-function index. Ophthalmic Physiol Opt 35:186-93 |
| Huang, Gang; Luo, Ting; Gast, Thomas J et al. (2015) Imaging Glaucomatous Damage Across the Temporal Raphe. Invest Ophthalmol Vis Sci 56:3496-504 |
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