Abstract

A program of research is proposed to use functional magnetic resonance imaging (FMRI) to analyze how visual information is organized and processed in human visual cortex. Using methods that have either been developed or refined by this group, nine visual cortical areas of interest will be identified in each subject using fMRI and displayed on a flatted cortical format.
Four aims will be pursued. First, how and where visual contours defined by different types of visual cues (luminance, hue, motion, etc.) are processed in visual cortex will be investigated. Second, changes in fMRI responses in response to large-field changes in luminance, color, and spatial frequency will be measured. Third, specific questions about visual motion processing will be addressed. Fourth, orientation sensitivity in different visual areas will be assessed by examining transient responses to changes in orientation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007980-11
Application #
6178985
Study Section
Special Emphasis Panel (ZRG1-VISA (01))
Program Officer
Oberdorfer, Michael
Project Start
1993-12-01
Project End
2001-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
11
Fiscal Year
2000
Total Cost
$249,554
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Koyama, Shinichi; Sasaki, Yuka; Andersen, George John et al. (2005) Separate processing of different global-motion structures in visual cortex is revealed by FMRI. Curr Biol 15:2027-32
Seiffert, Adriane E; Somers, David C; Dale, Anders M et al. (2003) Functional MRI studies of human visual motion perception: texture, luminance, attention and after-effects. Cereb Cortex 13:340-9
Sasaki, Yuka; Murakami, Ikuya; Cavanagh, Patrick et al. (2002) Human brain activity during illusory visual jitter as revealed by functional magnetic resonance imaging. Neuron 35:1147-56
Bar, M; Tootell, R B; Schacter, D L et al. (2001) Cortical mechanisms specific to explicit visual object recognition. Neuron 29:529-35
Sasaki, Y; Hadjikhani, N; Fischl, B et al. (2001) Local and global attention are mapped retinotopically in human occipital cortex. Proc Natl Acad Sci U S A 98:2077-82
Hadjikhani, N; Sanchez Del Rio, M; Wu, O et al. (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 98:4687-92
Tootell, R B; Hadjikhani, N (2001) Where is 'dorsal V4' in human visual cortex? Retinotopic, topographic and functional evidence. Cereb Cortex 11:298-311
Fischl, B; Sereno, M I; Tootell, R B et al. (1999) High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp 8:272-84
Somers, D C; Dale, A M; Seiffert, A E et al. (1999) Functional MRI reveals spatially specific attentional modulation in human primary visual cortex. Proc Natl Acad Sci U S A 96:1663-8
Mendola, J D; Dale, A M; Fischl, B et al. (1999) The representation of illusory and real contours in human cortical visual areas revealed by functional magnetic resonance imaging. J Neurosci 19:8560-72

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