Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY008197-08
Application #
2162088
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1989-08-01
Project End
1998-02-28
Budget Start
1996-08-01
Budget End
1998-02-28
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Pharmacology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Cook, T A; Ghomashchi, F; Gelb, M H et al. (2001) The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP hydrolysis in rod outer segments. J Biol Chem 276:5248-55
Cook, T A; Ghomashchi, F; Gelb, M H et al. (2000) Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits. Biochemistry 39:13516-23
Mou, H; Grazio 3rd, H J; Cook, T A et al. (1999) cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits. J Biol Chem 274:18813-20
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Yan, C; Bentley, J K; Sonnenburg, W K et al. (1994) Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. J Neurosci 14:973-84
Sonnenburg, W K; Beavo, J A (1994) Cyclic GMP and regulation of cyclic nucleotide hydrolysis. Adv Pharmacol 26:87-114
Stroop, S D; Beavo, J A (1992) Sequence homology and structure--function studies of the bovine cyclic-GMP-stimulated and retinal phosphodiesterases. Adv Second Messenger Phosphoprotein Res 25:55-71
Bentley, J K; Kadlecek, A; Sherbert, C H et al. (1992) Molecular cloning of cDNA encoding a ""63""-kDa calmodulin-stimulated phosphodiesterase from bovine brain. J Biol Chem 267:18676-82

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