Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY009631-11
Application #
6635623
Study Section
Visual Sciences C Study Section (VISC)
Program Officer
Mariani, Andrew P
Project Start
1991-08-01
Project End
2005-03-31
Budget Start
2003-04-01
Budget End
2005-03-31
Support Year
11
Fiscal Year
2003
Total Cost
$372,500
Indirect Cost
Name
Wayne State University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Yamazaki, Akio; Nishizawa, Yuji; Matsuura, Isao et al. (2013) Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: comparison with brain tau. Biochim Biophys Acta 1832:1549-59
Yamazaki, Akio; Hayashi, Fumio; Matsuura, Isao et al. (2011) Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation. FEBS J 278:1854-72
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Yamazaki, Akio; Bondarenko, Vladimir A; Matsuura, Isao et al. (2010) Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 1: identification of its inhibitory subunit complexes and their roles. Mol Cell Biochem 339:215-33
Bondarenko, Vladimir A; Hayashi, Fumio; Usukura, Jiro et al. (2010) Involvement of rhodopsin and ATP in the activation of membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC) by GC-activating proteins (GCAPs): a new model for ROS-GC activation and its link to retinal diseases. Mol Cell Biochem 334:125-39
Yamazaki, Akio; Yamazaki, Matsuyo; Yamazaki, Russell K et al. (2006) Illuminated rhodopsin is required for strong activation of retinal guanylate cyclase by guanylate cyclase-activating proteins. Biochemistry 45:1899-909
Yamazaki, Matsuyo; Usukura, Jiro; Yamazaki, Russell K et al. (2005) ATP binding is required for physiological activation of retinal guanylate cyclase. Biochem Biophys Res Commun 338:1291-8
Yamazaki, Akio; Yu, Hao; Yamazaki, Matsuyo et al. (2003) A critical role for ATP in the stimulation of retinal guanylyl cyclase by guanylyl cyclase-activating proteins. J Biol Chem 278:33150-60
Kajimura, Naoko; Yamazaki, Matsuyo; Morikawa, Kosuke et al. (2002) Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms. J Struct Biol 139:27-38
Desmeules, Philippe; Grandbois, Michel; Bondarenko, Vladimir A et al. (2002) Measurement of membrane binding between recoverin, a calcium-myristoyl switch protein, and lipid bilayers by AFM-based force spectroscopy. Biophys J 82:3343-50

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