Presbyopia, the age-related loss of the ability to accommodate, is the most common ocular affliction, affecting every human over the age of 45 years. Its pathophysiology is poorly understood. In the rhesus monkey, the only known animal model for the human condition, the ciliary muscle loses with age its configurational responses to cholinomimetic drugs or central stimulation. Although some evidence suggests that this loss of mobility may be due to restriction by a progressively inelastic posterior attachment, it is not clear that the muscle's contractile machinery continues to function normally, nor what roles the lens and zonules might play. The project will determine, in rhesus monkeys encompassing the entire species lifespan: 1) the real- time dynamics of ciliary muscle, lenticular and zonular movement in response to midbrain stimulation in living, surgically aniridic animals, by digital image analysis of Scheimpflug and goniovideographic recordings; and 2) the effect of extra- and intra-capsular lens extraction, posterior capsulotomy and complete posterior capsulectomy following extracapsular lens extraction, and regional zonulolysis on these real-time dynamics. These studies will generate new information about the pathophysiology of presbyopia in the rhesus monkey, the only known animal model for the human condition.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010213-03
Application #
2684558
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1996-04-01
Project End
2000-08-31
Budget Start
1998-04-01
Budget End
2000-08-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Croft, Mary Ann; Heatley, Gregg; McDonald, Jared P et al. (2016) Accommodative movements of the lens/capsule and the strand that extends between the posterior vitreous zonule insertion zone & the lens equator, in relation to the vitreous face and aging. Ophthalmic Physiol Opt 36:21-32
Flügel-Koch, Cassandra M; Croft, Mary Ann; Kaufman, Paul L et al. (2016) Anteriorly located zonular fibres as a tool for fine regulation in accommodation. Ophthalmic Physiol Opt 36:13-20
Croft, Mary Ann; McDonald, Jared P; Katz, Alexander et al. (2013) Extralenticular and lenticular aspects of accommodation and presbyopia in human versus monkey eyes. Invest Ophthalmol Vis Sci 54:5035-48
Croft, Mary Ann; Nork, T Michael; McDonald, Jared P et al. (2013) Accommodative movements of the vitreous membrane, choroid, and sclera in young and presbyopic human and nonhuman primate eyes. Invest Ophthalmol Vis Sci 54:5049-58
Lütjen-Drecoll, Elke; Kaufman, Paul L; Wasielewski, Rainer et al. (2010) Morphology and accommodative function of the vitreous zonule in human and monkey eyes. Invest Ophthalmol Vis Sci 51:1554-64
Croft, Mary Ann; McDonald, Jared P; Nadkarni, Nivedita V et al. (2009) Age-related changes in centripetal ciliary body movement relative to centripetal lens movement in monkeys. Exp Eye Res 89:824-32
Wendt, Mark; Croft, Mary Ann; McDonald, Jared et al. (2008) Lens diameter and thickness as a function of age and pharmacologically stimulated accommodation in rhesus monkeys. Exp Eye Res 86:746-52
Wasilewski, Rainer; McDonald, Jared P; Heatley, Gregg et al. (2008) Surgical intervention and accommodative responses, II: forward ciliary body accommodative movement is facilitated by zonular attachments to the lens capsule. Invest Ophthalmol Vis Sci 49:5495-502
Croft, Mary Ann; McDonald, Jared P; James, Rebecca J et al. (2008) Surgical intervention and accommodative responses, I: centripetal ciliary body, capsule, and lens movements in rhesus monkeys of various ages. Invest Ophthalmol Vis Sci 49:5484-94
Croft, Mary Ann; Glasser, Adrian; Heatley, Gregg et al. (2006) The zonula, lens, and circumlental space in the normal iridectomized rhesus monkey eye. Invest Ophthalmol Vis Sci 47:1087-95

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