Glaucoma is a leading cause of blindness and visual morbidity. Because the disease causes irreversible damage to neural tissue it is of upmost importance to identify glaucoma and its progression at the earliest possible stages. Through advancements in the use of optical coherence tomography (OCT) and other technologies, the long-term goal of this research project is to precisely and accurately detect ocular structural and functional changes associated with glaucoma and to identify eyes with glaucoma that are at risk for future disease progression. This is accomplished by consolidating our long-term data acquired from various generations of OCT technology over the last 19 years. By using innovative methods for image quality improvement along with signal morphing, it is now possible to reliably bridge data acquired by the different generations and manufacturers of OCT, creating the longest-term cohort of longitudinal OCT measurements of the retina and optic nerve head regions. Advanced retinal segmentation software will be applied enabling detailed discrimination of all retinal layers even in the presence of ocular co-morbidity coincident with glaucoma (a previous exclusion criteria), allowing maximal use of subject and patient data. Using this cohort, two methods will be uniquely applied for determining the long-term relationship between structure and function: Continuous-time hidden Markov model and Latent differential equation models. This would enhance understanding of the disease process and allow determination of the best methods to identify disease and its progression at various stages. We will utilize advanced innovative imaging technologies and methods to accurately and precisely detect evidence of early structural changes: Swept-source OCT, Adaptive-optics OCT and Polarization-sensitive OCT. These technologies will be used to image the retina, sclera and optic nerve head providing enhanced information of the lamina cribrosa and birefringence properties. Scans will be also acquired during and following provocative acute IOP elevation testing to asses the morphological and biomechanical responses as potential markers for current and future disease characterization. The outcomes of this research project will provide an innovative and enhanced evaluation of ocular structure and function in glaucoma that will expand our understanding of the disease pathophysiology, offer new diagnostic tools for early disease detection and disease progression and identify subjects at risk for rapid glaucoma progression.
The focus of this research project is on the development and refinement of innovative analytical methods and cutting-edge technologies that will substantially improve detection of glaucoma as well as disease progression in order to prevent blindness.
|Davidson, Edward H; Wang, Eric W; Yu, Jenny Y et al. (2016) Clinical Considerations for Vascularized Composite Allotransplantation of the Eye. J Craniofac Surg 27:1622-1628|
|Labriola, Leanne T; Legarreta, Andrew D; Legarreta, John E et al. (2016) IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP. Retin Cases Brief Rep 10:302-9|
|Kostanyan, Tigran; Sung, Kyung Rim; Schuman, Joel S et al. (2016) Glaucoma Structural and Functional Progression in American and Korean Cohorts. Ophthalmology 123:783-8|
|Murphy, Matthew C; Nau, Amy C; Fisher, Christopher et al. (2016) Top-down influence on the visual cortex of the blind during sensory substitution. Neuroimage 125:932-40|
|Wang, Bo; Lucy, Katie A; Schuman, Joel S et al. (2016) Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk. Invest Ophthalmol Vis Sci 57:3088-92|
|Dong, Zachary M; Wollstein, Gadi; Schuman, Joel S (2016) Clinical Utility of Optical Coherence Tomography in Glaucoma. Invest Ophthalmol Vis Sci 57:OCT556-67|
|Schuman, Joel S (2016) Optical Coherence Tomography in High Myopia. JAMA Ophthalmol 134:1040|
|Sivak, Wesley N; Davidson, Edward H; Komatsu, Chiaki et al. (2016) Ethical Considerations of Whole-Eye Transplantation. J Clin Ethics 27:64-7|
|Sigal, Ian A; Schuman, Joel S; Ishikawa, Hiroshi et al. (2016) A Problem of Proportions in OCT-Based Morphometry and a Proposed Solution. Invest Ophthalmol Vis Sci 57:484-5|
|Liu, Yutao; Bailey, Jessica Cooke; Helwa, Inas et al. (2016) A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium. Invest Ophthalmol Vis Sci 57:3974-81|
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