A major open - and very important question in cognitive neuroscience is: how and where are decisions made? Based on experimental work using a motion discrimination task, it is thought that perceptual decisions evolve within visuomotor regions of the brain controlling the generation of action. Where in the brain are decisions based on form computed? Are the principles gleaned from studying motion decisions applicable to form-based decisions? How do memories (mediated by the medial temporal lobe system) interact with perceptions to guide choices? We address these questions in four aims.
In Aim 1, we will determine performance accuracy and sensitivity of subjects in novel perceptual decision-making tasks that rely on form information. We will test the hypothesis that subjects show evidence of a decision-to-bound process in the performance of a form-based, perceptual decision-making task.
In Aim 2, we will determine the role of V4 extrastriate cortex in the perception of Glass patterns and in a novel perceptual decision-making task that relies on form discrimination. We will determine the relationship between neuronal activity in extrastriate cortical area V4 and behavioral performance in a form-based perceptual task in the same way that MT neuronal activity was characterized for motion perception. By building on our previous work, in Aim 3, we will determine the role of the superior colliculus in form-based perceptual decision-making and in Aim 4, we will determine whether the basal ganglia play a role in conveying memory information to motor circuits to guide form-based decisions under conditions of sensory uncertainty. The results of our experiments will shed new light on decision-making processing in visual areas of the brain and may provide a framework for understanding enigmatic symptoms seen in a number of neurological and neuropsychiatric diseases involving the basal ganglia.

Public Health Relevance

These experiments will determine how midlevel visual areas contribute to form-based decisions and how circuits in downstream areas relay memory information to guide action choices when sensory information is ambiguous. The results may shed light on important problems in visual cognitive neuroscience.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY013692-14
Application #
9388360
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Flanders, Martha C
Project Start
2001-12-01
Project End
2018-11-30
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
14
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Basso, Michele A; May, Paul J (2017) Circuits for Action and Cognition: A View from the Superior Colliculus. Annu Rev Vis Sci 3:197-226
Basso, Michele A (2016) Monkey neurophysiology to clinical neuroscience and back again. Proc Natl Acad Sci U S A 113:6591-3
Perugini, Alessandra; Ditterich, Jochen; Basso, Michele A (2016) Patients with Parkinson's Disease Show Impaired Use of Priors in Conditions of Sensory Uncertainty. Curr Biol 26:1902-10
Grimaldi, Piercesare; Lau, Hakwan; Basso, Michele A (2015) There are things that we know that we know, and there are things that we do not know we do not know: Confidence in decision-making. Neurosci Biobehav Rev 55:88-97
Crapse, Trinity B; Basso, Michele A (2015) Insights into decision making using choice probability. J Neurophysiol 114:3039-49
Mahamed, Safraaz; Garrison, Tiffany J; Shires, Joel et al. (2014) Stimulation of the substantia nigra influences the specification of memory-guided saccades. J Neurophysiol 111:804-16
Powers, Alice S; Basso, Michele A; Evinger, Craig (2013) Blinks slow memory-guided saccades. J Neurophysiol 109:734-41
Li, Xiaobing; Basso, Michele A (2011) Cues to move increased information in superior colliculus tuning curves. J Neurophysiol 106:690-703
Basso, M A; Sommer, M A (2011) Exploring the role of the substantia nigra pars reticulata in eye movements. Neuroscience 198:205-12
Kim, Byounghoon; Basso, Michele A (2010) A probabilistic strategy for understanding action selection. J Neurosci 30:2340-55

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